N-DBCO-N-bis(PEG2-NHS ester) Chemical Properties

Boiling point:

964.5±75.0 °C(Predicted)

Density 

1.41±0.1 g/cm3(Predicted)

storage temp. 

Storage temp. -20°C

pka

-0.20±0.20(Predicted)

form 

Solid

color 

Light yellow to yellow

N-DBCO-N-bis(PEG2-NHS ester) Usage And Synthesis

Description

N-DBCO-N-bis(PEG2-NHS ester) is a click chemistry reagent with NHS ester groups. The NHS esters can be used to label the primary amines (-NH2) of proteins and other amine-containing molecules.The DBCO group allows to react with azide molecule via copper-free Click Chemistry.

Uses

N-DBCO-N-bis(PEG2-C2-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-DBCO-N-bis(PEG2-C2-NHS ester) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

N-DBCO-N-bis(PEG2-NHS ester)(2128735-29-3)Related Product Information

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