E4CPG
E4CPG Basic information
- Product Name:
- E4CPG
- Synonyms:
-
- E4CPG
- (RS)-ALPHA-ETHYL-4-CARBOXYPHENYLGLYCINE
- (RS)-α-Ethyl-4-carboxyphenylglycine
- 4-(1-amino-1-carboxypropyl)benzoic acid
- Benzeneacetic acid, α-amino-4-carboxy-α-ethyl-
- Metabotropic glutamate receptors,metabotropic,Inhibitor,mGluR,mGluRs,inhibit,(RS)-ECPG,E4CPG,E-4CPG
- CAS:
- 170846-89-6
- MF:
- C11H13NO4
- MW:
- 223.23
- Product Categories:
-
- Glutamate receptor
- Mol File:
- Mol File
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E4CPG Chemical Properties
- Boiling point:
- 431.3±40.0 °C(Predicted)
- Density
- 1.337±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- H2O : < 0.1 mg/mL (insoluble)DMSO : < 1 mg/mL (insoluble or slightly soluble)
- form
- Powder
- pka
- 1.76±0.10(Predicted)
- color
- White to off-white
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E4CPG Usage And Synthesis
Uses
E4CPG is a group I/group II metabotropic glutamate receptor antagonist.
in vivo
E4CPG (3-30 nmol/site (i.t.), 1-10 μmol/paw (i.pl.), and 1-10 nmol/site (i.c.v.)) significantly inhibits the nociception induced by the Glutamate-injection (i.pl.; 30 μmol/paw), and the maximal inhibition values for the antinociceptive action of E4CPG in Glutamate-induced nociception are 48% (i.pl.), 49% (i.t.) and 40% (i.c.v.) [4].
E4CPG (35 nM/3.5 μL, i.c.v.) completely blocks long-term depression (LTD) induced by the group I mGluR agonist Dihydroxyphenylglycine (DHPG, 100 nM/5 μL, i.c.v.) in male Sprague-Dawley rats[5].
| Animal Model: | Male Swiss mice (25-35 g)[4] |
| Dosage: | 3-30 nmol/site (i.t.), 1-10 μmol/paw (i.pl.) and 1-10 nmol/ site (i.c.v.) |
| Administration: | Single injection |
| Result: | The maximal inhibition values for the antinociceptive action of E4CPG in glutamate-induced nociception were 48% (i.pl.), 49% (i.t.) and 40% (i.c.v.). |
| Animal Model: | Male Sprague-Dawley rats[5] |
| Dosage: | 35 nM/3.5 μL |
| Administration: | Single injection, i.c.v. |
| Result: | Completely blocked LTD induced by the group I mGluR agonist dihydroxyphenylglycine (DHPG). |
IC 50
mGluR
storage
Room temperature
E4CPGSupplier
3B Pharmachem (Wuhan) International Co.,Ltd.
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- 821-50328103-801 18930552037
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Haoyuan Chemexpress Co., Ltd.
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- 0551-66399836 18955197623
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- 021-52996696，15000506266 15000506266
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