4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE
4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE Basic information
- Product Name:
- 4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE
- Synonyms:
-
- 4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE
- A 77-01
- A-77-01
- A77-01
- 4-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]quinoline A 77-01
- 4-[3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoline
- CS-1775
- 4-[5-(6-methylpyridin-2-yl)-1~{H}-pyrazol-4-yl]quinoline
- CAS:
- 607737-87-1
- MF:
- C18H14N4
- MW:
- 286.33
- Product Categories:
-
- Inhibitors
- Mol File:
- 607737-87-1.mol
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4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; ≥14.3 mg/mL in DMSO; ≥8.84 mg/mL in EtOH with gentle warming and ultrasonic
- form
- solid
- color
- Off-white to light yellow
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4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE Usage And Synthesis
Uses
A 77-01 is a potent inhibitor of transforming growth factor (TGF)-β type I receptor superfamily activin-like kinase ALK5 with an IC50 of 25 nM[1].
storage
Store at +4°C
References
[1] Tojo M, et al. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Sci. 2005 Nov;96(11):791-800. DOI:10.1111/j.1349-7006.2005.00103.x
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