3-IODO-4-METHOXY-BENZALDEHYDE Chemical Properties

Melting point:

107-112℃

Boiling point:

325.0±32.0 °C(Predicted)

Density 

1.780±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

form 

Solid

color 

White to off-white/yellow

Sensitive 

Air & Light Sensitive

InChI

InChI=1S/C8H7IO2/c1-11-8-3-2-6(5-10)4-7(8)9/h2-5H,1H3

InChIKey

RVWOHBWQJGLXIJ-UHFFFAOYSA-N

SMILES

C(=O)C1=CC=C(OC)C(I)=C1

Safety Information

Hazard Codes 

Xn,N

Risk Statements 

22-50

Safety Statements 

61

RIDADR 

UN 2811 6.1 / PGIII

WGK Germany 

3

HazardClass 

6.1

HS Code 

2912290090

3-IODO-4-METHOXY-BENZALDEHYDE Usage And Synthesis

Synthesis

General procedure for the synthesis of compounds (CAS:2314-37-6) from p-methoxybenzaldehyde: To a solution (0.1 M) of dichloromethane (CH2Cl2) or 1,2-dichloroethane ((CH2Cl)2) in stirring (1 mmol) of the substrate (1 mmol), Ph3PAuNTf2 (0.025 mmol, 19 mg; if using the 2:1 complex of Ph3PAuNTf2 with toluene), followed by N-iodosuccinimide (1.1 mmol, 248 mg). The reaction mixture was stirred at room temperature or reacted under reflux conditions until complete conversion of the feedstock. Upon completion of the reaction, the solvent was removed under reduced pressure and the crude product was purified by fast column chromatography using different ratios of hexane and ethyl acetate (EtOAc) as eluents to give the final pure target product.

References

[1] European Journal of Organic Chemistry, 2000, # 8, p. 1527 - 1533
[2] European Journal of Organic Chemistry, 2012, # 30, p. 5935 - 5942,8
[3] Synthesis, 2010, # 16, p. 2776 - 2786
[4] Organic letters, 2003, vol. 5, # 4, p. 415 - 418
[5] Tetrahedron Letters, 1997, vol. 38, # 35, p. 6305 - 6306

3-IODO-4-METHOXY-BENZALDEHYDE(2314-37-6)Related Product Information

• 3-Iodo-4-methoxybenzoic acid
• Desethylamiodarone
• METHYL 3-IODO-4-METHOXYBENZOATE
• Amiodarone
• Amiodarone hydrochloride
• 3-Iodo-4,5-dimethoxybenzaldehyde
• Acetiromate
• 4-(4'-HYDROXY-3'-IODOPHENOXY)-3,5-DIIODO-BENZOIC ACID
• 3,5-DIIODO-4-METHOXYBENZHYDRAZIDE
• 3,5-DIIODO-4'-(4-HYDROXYPHENOXY)BENZOIC ACID
• AKOS B005679
• METHYL 3,5-DIIODO-4-METHOXYBENZOATE
• 3-IODO-4-METHOXY-BENZALDEHYDE
• 3,5-DIIODO-4(4'-METHOXYPHENOXY)BENZOIC ACID
• 2-IODO-6-METHOXY-BENZALDEHYDE
• AKOS B005595
• 3,5,3',5'-TETRAIODOTHYROFORMIC ACID
• ASISCHEM R31119