1H-pyrrolo[2,3-b]pyridine-6-carbonitrile Chemical Properties

Melting point:

187.4 °C

Boiling point:

463.9±28.0 °C(Predicted)

Density 

1.29±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

pka

6.56±0.40(Predicted)

Safety Information

HS Code 

2933998090

1H-pyrrolo[2,3-b]pyridine-6-carbonitrile Usage And Synthesis

Description

7-Azaindole, as a bioisostere of indole or purine, is widely used in drug development. Among them, 1H-pyrrolo[2,3-b]pyridine-6-carbonitrile is a key intermediate for the synthesis of a class of selective cyclin-dependent kinase (CDK) 7 inhibitors. Among mammalian CDKs, CDK7 has a unique integrated kinase activity that helps regulate the cell cycle and gene transcription. 1H-pyrrolo[2,3-b]pyridine-6-carbonitrile can be prepared using 7-azaindole-7-oxide as a raw material.

Chemical Properties

Class white powder

1H-pyrrolo[2,3-b]pyridine-6-carbonitrile(189882-33-5)Related Product Information

• 6-NITRO-1H-PYRROLO[2,3-B]PYRIDINE
• 4-METHYL-7-AZAINDOLE
• 1,7-DIDEAZAADENINE
• 4-FLUORO-7-AZAINDOLE
• 1H-Pyrrolo[2,3-b]pyridine, 6-fluoro-
• 1H-PYRROLO[2,3-B]PYRIDINE-6-CARBONITRILE
• 6-METHYL-1H-PYRROLO[2,3-B]PYRIDINE