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Tofacitinib Impurity K

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Tofacitinib Impurity K Basic information

Product Name:
Tofacitinib Impurity K
Synonyms:
  • Azilsartan medoxomil impurity332
  • 3-((3R,4R)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanoic acid (Tofacitinib Impurity)
  • 1-Piperidinepropanoic acid, 4-methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-, (3R,4R)-
CAS:
2328165-36-0
MF:
C16H21N5O3
MW:
331.38
Mol File:
2328165-36-0.mol
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Tofacitinib Impurity K Chemical Properties

Density 
1.367±0.06 g/cm3(Predicted)
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
4.96±0.32(Predicted)
color 
White to Off-White
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Tofacitinib Impurity K Usage And Synthesis

Uses

3-((3R,4R)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanoic Acid is an impurity of Tofacitinib (T528000), an enantiopure stereoisomer of the drug, Janus kinase 3(Jak3) inhibitor (CP-690,550) that has been found to inhibit selected members of the STE7 and STE20 subfamily of kinases.

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