Befovacimab CAS#: 2156634-62-5

Befovacimab Basic information

Product Name:

Befovacimab

Synonyms:

Befovacimab
Research Grade Befovacimab (DHC82801)
Research Grade Befovacimab

CAS:

2156634-62-5

MW:

0

Mol File:

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Befovacimab Usage And Synthesis

Uses

Befovacimab (BAY 1093884) is a fully human monoclonal IgG2 antibody able to bind to tissue factor pathway inhibitor (TFPI). Befovacimab can be used for haemophilia A/B research[1].

in vivo

In monkey plasma, Befovacimab exhibits an IC₅₀ of 4.65 nM and 6.19 nM for free TFPI and diluted prothrombin time (dPT), respectively^[1].
Befovacimab (5 and 20 mg/kg; intravenous and subcutaneous administration) dose‐dependent decreases in TFPI concentration and clotting time in female cynomolgus monkeys in vivo^[1].

References

[1] Maria Elisa Mancuso, et al. Befovacimab, an anti-tissue factor pathway inhibitor antibody: Early termination of the multiple-dose, dose-escalating Phase 2 study due to thrombosis. Haemophilia. 2022 Sep;28(5):702-712. DOI:10.1111/hae.14595
[2] Jian-Ming Gu, et al. Mechanistic Modeling of the Pharmacodynamic and Pharmacokinetic Relationship of Tissue Factor Pathway Inhibitor-Neutralizing Antibody (BAY 1093884) in Cynomolgus Monkeys. AAPS J. 2017 Jul;19(4):1186-1195. DOI:10.1208/s12248-017-0086-4

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