6-Bromo-7-(difluoromethyl)-1,2,3,4-tetrahydroquinoline Chemical Properties

Boiling point:

328.6±42.0 °C(Predicted)

Density 

1.485±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

pka

3.60±0.20(Predicted)

Appearance

White to yellow Solid

6-Bromo-7-(difluoromethyl)-1,2,3,4-tetrahydroquinoline Usage And Synthesis

Uses

6-Bromo-7-(difluoromethyl)-1,2,3,4-tetrahydroquinoline is an intermediate in the synthesis of GNE-781 (D447825), a derivative of a highly advanced, potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein (CBP). Inhibition of the bromodomain of the transcriptional regulator CBP/P300 is an especially interesting new therapeutic approach in oncology.

6-Bromo-7-(difluoromethyl)-1,2,3,4-tetrahydroquinoline(1936429-80-9)Related Product Information

• 7-METHYL-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE
• 6-Bromo-7-(trifluoromethyl)-1,2,3,4-tetrahydroquinoline
• Quinoline, 1,2,3,4-tetrahydro-6-(methylthio)-
• 7-Quinolinecarboxylic acid, 6-bromo-1,2,3,4-tetrahydro-
• 7-Methyl-1,2,3,4-tetrahydroquinoline
• 1,2,3,4-tetrahydroquinoline-2-carboxamide
• 6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline