8-BROMOQUINOLIN-2(1H)-ONE Chemical Properties

Melting point:

196-198 °C

Boiling point:

390.2±42.0 °C(Predicted)

Density 

1.620±0.06 g/cm3(Predicted)

storage temp. 

Room temperature.

pka

10.70±0.70(Predicted)

form 

Peachy beige fine crystalline needles

Appearance

Light yellow to light brown Solid

InChI

InChI=1S/C9H6BrNO/c10-7-3-1-2-6-4-5-8(12)11-9(6)7/h1-5H,(H,11,12)

InChIKey

HGJBIJWBYATVQY-UHFFFAOYSA-N

SMILES

N1C2=C(C=CC=C2Br)C=CC1=O

Safety Information

HS Code 

2933499090

8-BROMOQUINOLIN-2(1H)-ONE Usage And Synthesis

Uses

8-Bromoquinolin-2(1H)-one is an organic compound that inhibits the production of inflammatory substances in the body. It is a long-chain alkene and a synthetic substance that is used to prepare pharmaceuticals.

Application

8-Bromoquinolin-2(1H)-one has been shown to have anti-cancer properties, as well as an inhibitory effect on inflammation. The drug is synthesized by reacting benzonitrile with bromine and ammonia in a reaction system. 8-Bromoquinolin-2(1H)-one inhibits the synthesis of prostaglandin E2 (PGE2) by inhibiting cyclooxygenase and lipoxygenase enzymes. It also binds with high affinity to the enzyme phospholipase A 2 (PLA 2 ), which results in a rapid hydrolysis of phospholipids and production of arachidonic acid, which leads to increased levels of PGE2.

8-BROMOQUINOLIN-2(1H)-ONE(67805-67-8)Related Product Information

• 8-BROMO-2H-ISOQUINOLIN-1-ONE
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• 8-NITROQUINAZOLIN-4-OL
• 8-BROMOQUINOLIN-2(1H)-ONE
• ETHYL 6,8-DIBROMO-2-OXO-1,2-DIHYDRO-3-QUINOLINECARBOXYLATE