2'-MECCPA Chemical Properties

Boiling point:

643.3±65.0 °C(Predicted)

Density 

1.76±0.1 g/cm3(Predicted)

storage temp. 

Store at +4°C

solubility 

Soluble to 25 mM in DMSO

form 

Powder

pka

13.13±0.70(Predicted)

color 

Off-white to light yellow

2'-MECCPA Usage And Synthesis

Uses

2''-?MeCCPA is an inhibitor of forskolin-stimulated adenylyl cyclase. It is also a selective A1 adenosine receptor agonist.

Definition

ChEBI: 2-[2-chloro-6-(cyclopentylamino)-9-purinyl]-5-(hydroxymethyl)-3-methyloxolane-3,4-diol is a purine nucleoside.

Biological Activity

Potent and highly selective agonist at A 1 adenosine receptors (K i values are 3.3, 9580, 37600 and 1150 nM for human recombinant A 1 , A 2A , A 2B and A 3 receptors respectively). Acts as a full agonist; inhibits forskolin-stimulated adenylyl cyclase activity in rat cortical membranes with an IC 50 value of 13.1 nM.

storage

Store at +4°C

2'-MECCPA(205171-12-6)Related Product Information

• 2-CHLORO-N-METHYL-9H-PURIN-6-AMINE
• CCPA
• N6-CYCLOPENTYLADENOSINE
• 2-chloro-N-(1-methylethyl)pyrimidin-4-amine
• 2-chloro-2',3'-dideoxyadenosine
• 2-Chloroadenosine
• Cladribine
• 2'-MECCPA