N6-CYCLOPENTYLADENOSINE Chemical Properties

Melting point:

78.8 °C

Boiling point:

673.4±65.0 °C(Predicted)

Density 

1.78±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

H2O: soluble1.7mg/mL

form 

solid

pka

13.12±0.70(Predicted)

color 

white to off-white

Safety Information

WGK Germany 

3

HS Code 

29349990

N6-CYCLOPENTYLADENOSINE Usage And Synthesis

Uses

N6-Cyclopentyladenosine is a selective Adenosine A1-R agonist with Ki values of 2.3, 790 and 43 nM for human A1, A2A and A3 receptors respectively and EC50 value of 18600 nM for hA2B. It has also shown its efficacy against organophosphate toxcity.

Uses

N⁶-Cyclopentyladenosine has been used to study its effect on the cavernosal smooth muscle cells from lean and db/db (obesity and type II diabetes caused by a leptin receptor mutation) mice.

Biological Activity

Potent and selective adenosine A 1 receptor agonist (K i values are 2.3, 790 and 43 nM for human A 1 , A 2A and A 3 receptors respectively; EC 50 = 18600 nM for hA 2B ). Centrally active following systemic administration in vivo .

Biochem/physiol Actions

N6-Cyclopentyladenosine (CPA) is an adenosine derivative and a potent A1 adenosine receptor agonist. It acts as an anticonvulsant and might exhibit protective actions against aminophylline (AMPH)-induced seizures.

storage

Desiccate at +4°C

N6-CYCLOPENTYLADENOSINE(41552-82-3)Related Product Information

• CYCLOPENTYLADENOSINE, 2-CHLORO-N6-[CYCLOPENTYL-2,3,4,5-3H]-
• (2S)-N6-[2-ENDO-NORBORNYL]ADENOSINE
• GR 79236
• 2'-MECCPA
• 2-CHLORO-N6-CYCLOPENTYLADENOSINE,2-CHLORO-N-CYCLOPENTYLADENOSINE
• N6-CYCLOPENTYLADENOSINE