PYRAZOL-1-YL-METHANOL Chemical Properties

Melting point:

89-90℃ (ethanol water )

Boiling point:

214.0±23.0℃ (760 Torr)

Density 

1.21±0.1 g/cm3 (20 ºC 760 Torr)

Flash point:

83.2±22.6℃

storage temp. 

Sealed in dry,Room Temperature

pka

13.14±0.10(Predicted)

Appearance

White to off-white Solid

PYRAZOL-1-YL-METHANOL Usage And Synthesis

Synthesis

To a round-bottomed flask containing pyrazole (144 mmol, 100 g) and methanol (~200 mL), formaldehyde (131 g, 37% aqueous solution) was slowly added. The reaction mixture was stirred continuously at 25 °C for 4 h until a homogeneous solution (0193) was formed. Subsequently, the solvent was removed by distillation under reduced pressure and dried under vacuum for several hours to give the final 1-pyrazole methanol (127 g, 90% yield).

References

[1] Patent: WO2016/191677, 2016, A1. Location in patent: Paragraph 0110

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