elliptinium acetate
elliptinium acetate Basic information
- Product Name:
- elliptinium acetate
- Synonyms:
-
- elliptinium acetate
- Elliptinium
- 2-Methyl-9-hydroxyellipticinium acetate
- Ellipticine acetomethylate
- N2-Methyl-9-hydroxyellipticinium acetate
- 6H-Pyrido[4,3-B]carbazolium, 9-hydroxy-2,5,11-trimethyl-acetate (salt)
- 9-Hydroxy-2-methylellipticinium acetate
- H9m2E
- CAS:
- 58337-35-2
- MF:
- C20H20N2O3
- MW:
- 336.3844
- EINECS:
- 261-216-0
- Mol File:
- 58337-35-2.mol
elliptinium acetate Usage And Synthesis
Uses
Elliptinium acetate (NSC 264137) is a DNA intercalating agent that is highly cytotoxic to L1 210 cells and covalently binds to nucleic acids from L1210 cells. Elliptinium acetate can be used in cancer research, particularly in metastatic breast cancer[1][2].
Anticancer Research
It is an ellipticine derivative and is obtained from Bleekeria vitensis, a Fijian medicinalplant. It is used to treat breast cancer (Shoeb 2006).
References
[1] Dugue B, et al. Covalent binding of elliptinium acetate (NSC 264137) to nucleic acids of L1210 cells in culture. Cancer Res. 1986 Aug;46(8):3828-33. PMID:2425935
[2] Arteaga CL, et al. Elliptinium, a DNA intercalating agent with broad antitumor activity in a human tumor cloning system. Eur J Cancer Clin Oncol. 1987 Nov;23(11):1621-6. DOI:10.1016/0277-5379(87)90440-8