(4-Fluoro-3,5-dimethylphenyl)hydrazine hydrochloride Chemical Properties

InChI

InChI=1S/C8H11FN2.ClH/c1-5-3-7(11-10)4-6(2)8(5)9;/h3-4,11H,10H2,1-2H3;1H

InChIKey

OPXRKRXGKCMCPJ-UHFFFAOYSA-N

SMILES

N(C1C=C(C)C(F)=C(C)C=1)N.Cl

(4-Fluoro-3,5-dimethylphenyl)hydrazine hydrochloride Usage And Synthesis

Description

(4-Fluoro-3,5-dimethylphenyl)hydrazine hydrochloride is an organic compound containing a fluorobenzene ring and a hydrazine functional group. It usually exists as a white solid hydrochloride salt with the molecular formula C₈H₁₂ClFN₂ and a molecular weight of 190.65. As an aromatic hydrazine derivative, it exhibits high reactivity in organic synthesis, primarily due to its hydrazine group, making it an important precursor for constructing complex heterocyclic compounds, especially pyrazole ring systems.

Uses

The primary use of (4-Fluoro-3,5-dimethylphenyl)hydrazine hydrochloride is as a key intermediate in drug synthesis, particularly in the development of novel oral hypoglycemic agents. For example, it is a key intermediate in the synthetic route of ofoglione (a novel oral glucagon-like peptide-1 receptor agonist for the treatment of type 2 diabetes).