1H-Indole-2-carboxamide, 4-fluoro-7-methyl-N-[(1R,3S)-3-[(3S)-3-[methyl(methylsulfonyl)amino]-1-pyrrolidinyl]cyclohexyl]- Chemical Properties

Density 

1.33±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO: 2 mg/mL, clear

form 

Solid

pka

14.79±0.40(Predicted)

color 

Off-white to yellow

SMILES

FC1=C2C(NC(C(N[C@H]3C[C@@H](N4C[C@H](CC4)N(C)S(C)(=O)=O)CCC3)=O)=C2)=C(C=C1)C.[0.75H2O]

1H-Indole-2-carboxamide, 4-fluoro-7-methyl-N-[(1R,3S)-3-[(3S)-3-[methyl(methylsulfonyl)amino]-1-pyrrolidinyl]cyclohexyl]- Usage And Synthesis

Biological Activity

EPZ-719 is a novel and potent SETD2 inhibitor ( IC50 = 0.005 μM) with a high selectivity over other histone methyltransferases.

References

[1]. Lampe JW, et al. Discovery of a First-in-Class Inhibitor of the Histone Methyltransferase SETD2 Suitable for Preclinical Studies. ACS Med Chem Lett. 2021 Aug 24;12(10):1539-1545.