SR 31747
SR 31747 Basic information
- Product Name:
- SR 31747
- Synonyms:
-
- SR 31747
- (Z)-N-[3-(3-CHLORO-4-CYCLOHEXYLPHENYL)PROP-2-ENYL]-N-ETHYLCYCLOHEXYLAMINE HYDROCHLORIDE
- 3-(3-Chloro-4-cyclohexylphenyl)-N-cyclohexyl-N-ethyl-2(Z)-propenylaMine
- 3-(3-Chloro-4-cyclohexylphenyl)-N-cyclohexyl-N-ethyl-2(Z)-propenylaMine hydrochloride
- (Z)-N-(3-(3-Chloro-4-cyclohexylphenyl)allyl)-N-ethylcyclohexanamine
- HKHPCMBPASXYGP-KVVVOXFISA-N
- (Z)-N-(3-(3-Chloro-4-cyclohexylphenyl)allyl)-N-ethylcyclohexanamine hydrochloride
- SR 31747,SR31747
- CAS:
- 132173-07-0
- MW:
- 0
- Mol File:
- 132173-07-0.mol
SR 31747 Chemical Properties
- form
- Solid
- color
- White to off-white
SR 31747 Usage And Synthesis
Uses
SR-31747 is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase[1][2].
in vivo
In vivo, SR-31747 dramatically blocks lipopolysaccharide-induced production of IL-1, IL-6 and TNF-α in a dose-dependent manner (ED50, 2 mg/kg). SR-31747 probably abrogated monokine production through an indirect mechanism that involves endogenous corticosteroids. This conclusion was supported by in vivo experiments that shows that: 1) ablation of corticosteroids by use of Mifepristone or adrenalectomy suppress the effect of SR-31747; 2) administration of SR-31747 induces an enhancement of the corticosterone level. SR-31747 improves the survival of animals with endotoxinic shock as a result of monokine inhibition[1].
References
[1] Derocq JM, et al. In vivo inhibition of endotoxin-induced pro-inflammatory cytokines production by the sigma ligand SR 31747. J Pharmacol Exp Ther. 1995 Jan;272(1):224-30. PMID:7815336
[2] Silve S, et al. The immunosuppressant SR 31747 blocks cell proliferation by inhibiting a steroid isomerase in Saccharomyces cerevisiae. Mol Cell Biol. 1996 Jun;16(6):2719-27. DOI:10.1128/MCB.16.6.2719
SR 31747Supplier
- Tel
- +86-（0）57185586718; +8613336195806
- sales@capot.com
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Tel
- 18818260767
- sales@chemegen.com
- Tel
- 88888888888
- hongquchem@qq.com
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com