SODIUM CAMPTOTHECIN
SODIUM CAMPTOTHECIN Basic information
- Product Name:
- SODIUM CAMPTOTHECIN
- Synonyms:
-
- 20(s)-camptothecinsodiumsalt
- 21,22-secocamptothecin-21-oicacid,monosodiumsalt
- camptothecin,sodiumsalt
- camptothecinesodium
- camptothecinsodium
- SODIUM CAMPTOTHECIN
- (αS)-α-Ethyl-9,11-dihydro-α-hydroxy-8-(hydroxymethyl)-9-oxoindolizino[1,2-b]quinoline-7-acetic acid sodium salt
- 21,22-Secocamptothecin-21-oic acid, monosodium salt 20(S)-camptothecin sodium salt
- CAS:
- 25387-67-1
- MF:
- C20H17N2NaO5
- MW:
- 388.35
- Mol File:
- 25387-67-1.mol
SODIUM CAMPTOTHECIN Chemical Properties
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Solid
- color
- Light yellow to light brown
SODIUM CAMPTOTHECIN Usage And Synthesis
Uses
Sodium Camptothecin is the salt form of Camptothecin.
Synthesis
7689-03-4
25387-67-1
1.045 g of (S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione (CPT lactone) was accurately weighed in a sterile round bottom flask (250 mL). Water equivalent to 20% of the final volume was added to give a final concentration of CPT of 25 mM.Subsequently, 3.34 g of 1N NaOH solution was added to the inhomogeneous mixture, ensuring that the molar ratio of CPT to NaOH was 1:1.05.The mixture was stirred vigorously at 50°C until complete dissolution, a process that took about 1 h, indicating that the CPT lactone had been quantitatively converted to its water-soluble carboxylate form. It was shown that raising the temperature to 90°C further accelerated this conversion process. Although stirring for 4-6 hours has no significant effect on the chemical stability of CPT, it is recommended that this stirring time be maintained to ensure a complete reaction. Upon completion of the reaction, the solution is cooled to room temperature and can be stored under light conditions at 4°C for at least 24 hours. (Long-term storage stability of CPT-Na stock solutions will be discussed subsequently.) The pH of the final solution should be maintained between 10 and 11.5.
References
[1] Patent: EP1547582, 2005, A1. Location in patent: Page/Page column 10
[2] Patent: EP1547580, 2005, A1. Location in patent: Page/Page column 13
SODIUM CAMPTOTHECINSupplier
- Tel
- 0838-5675166 15883665058
- nbcxkj@126.com
- Tel
- 010-010-82967028 13522913783
- 2355560935@qq.com
- Tel
- 010-56205725
- waley188@sohu.com
- Tel
- 021-62960152
- 934678158@qq.com
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com