(R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL Chemical Properties

Melting point:

89-91°C

Boiling point:

499.4±45.0 °C(Predicted)

Density 

1.150±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: ≥20mg/mL

pka

13.93±0.20(Predicted)

form 

powder

color 

off-white to light brown

Safety Information

Hazard Codes 

N

Risk Statements 

50

Safety Statements 

61

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

3

(R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL Usage And Synthesis

Description

Volinanserin is a potent and selective antagonist of the serotonin receptor 5-HT_2A (K_i = 0.36-0.85 nM). It weakly binds 5-HT_2C, α₁-adrenergic, and sigma receptors (K_i = 88, 128, and 87 nM) and much less effectively associates with other serotonin, dopamine, adrenergic, muscarinic acetylcholine receptors and monoamine transporters. Volinanserin displays antipsychotic activity, attenuates impulsivity, and augments antidepressant effects in vivo.

Chemical Properties

Colourless solid

Uses

Volinanserin is a serotonin receptor 5-HT2A antagonist; anti-psychotic.

Uses

As a serotonin 5-HT2A receptor antagonist, Volinanserin Hydrochloride Salt can be used as potential controls in various biological studies.

General Description

M100907 blocks the serotonin 2A (5-HT2A) receptors and imposes antidepressant-like effects. It may be used for treating dopaminergic anomalies.

Biochem/physiol Actions

M100907 is a selective 5-HT2A Antagonist.

storage

+4°C

(R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL(139290-65-6)Related Product Information

• 4-(3-METHOXY-BENZYL)-PIPERIDINE
• ALPHA-PHENYL-1-(2-PHENYLETHYL)-4-PIPERIDINEMETHANOL
• CHEMBRDG-BB 4010734
• 4-(2-METHOXY-BENZYL)-PIPERIDINE
• 3-PIPERIDIN-4-YLMETHYL-PHENOL
• PHENYL-PIPERIDIN-4-YL-METHANOL
• (R)-(+)-ALPHA-(3-HYDROXY-2-METHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL
• (+/-)-ALPHA-(2,3-DIMETHOXY-PHENYL)-1-[2-(4-FLUOROPHENYL)ETHYL]-4-PIPERIDINE-METHANOL
• Volinanserin Hydrochloride Salt