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PantoprazoleSodiumSesquihydrate

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PantoprazoleSodiumSesquihydrate Basic information

Product Name:
PantoprazoleSodiumSesquihydrate
Synonyms:
  • Pantoprazole sodium hydrate
  • 1H-Benzimidazole, 5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl)sulfinyl)-, sodium salt, hydrate (2:3)
  • Unii-6871619Q5x
  • 6-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt hydrate (2:2:3)
  • SKF-96022 SODIUM HYDRATE
  • Pantoprazole sodium sesquihydrate CRS
  • Pantoprazole for system suitability CRS
  • BY1023 (sodium hydrate)
CAS:
164579-32-2
MF:
C16H18F2N3NaO5S
MW:
425.38
EINECS:
1312995-182-4
Mol File:
164579-32-2.mol
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PantoprazoleSodiumSesquihydrate Chemical Properties

storage temp. 
4°C, protect from light
solubility 
Freely soluble in water and in ethanol (96 per cent), practically insoluble in hexane.
form 
Solid
color 
White to off-white
Major Application
pharmaceutical (small molecule)
InChI
1S/C16H16F2N3O4S.Na.H2O/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16;;/h3-7,15-16,21H,8H2,1-2H3;;1H2/q-1;+1;
InChIKey
QHNXIKDJFYGZTL-UHFFFAOYSA-N
SMILES
[Na+].FC(F)Oc1cc2c(cc1)[N-]C(N2)[S](=O)Cc3nccc(c3OC)OC.O
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
nwg
HS Code 
2933399090
Storage Class
11 - Combustible Solids
Hazard Classifications
Acute Tox. 4 Oral
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PantoprazoleSodiumSesquihydrate Usage And Synthesis

Chemical Properties

White or almost white powder.

Uses

Pantoprazole Sodium Hydrate is a metabolite of Pantoprazole Sodium Salt which is an antiulcerative. Gastric pump inhibitor. The free acid, Pantoprazole is a prodrug used in the treatment of acid related disorders and Helicobacter pylori infections.

Uses

Treatment of various acid-related gastrointestinal diseases, including acute erosive esophagitishealing and maintenance, treatment of hypersecretory conditions, Zollinger-Ellison Syndrome (ZES), and eradication of Helicobacter pylori infection.

brand name

Protonix (Wyeth).

in vivo

Pantoprazole sodium hydrate (BY1023 sodium hydrate; 200 mg/kg; IP; once a week for 3 weeks) significantly increases tumor growth delay of MCF-7 xenografts combined with Doxorubicin[1].
Pantoprazole sodium hydrate (0.3-3 mg/kg, p.o.) dose-dependently decreases both basal acid secretion in pylorus-ligated rats and the stimulated acid secretion induced by mepirizole in acute fistula rats[4].

Animal Model:Mice bearing MCF-7 or A431 xenografts[1]
Dosage:200 mg/kg
Administration:IP; once a week for 3 weeks; alone or 2 hours before Doxorubicin (6 mg/kg i.v.)
Result:Showed even greater growth delay of MCF-7 xenografts with Doxorubicin compared with the single-dose combination.
Significantly increased tumor growth delay with a single dose with Doxorubicin.
There is no effect on growth delay alone.

PantoprazoleSodiumSesquihydrateSupplier

Beijing Ouhe Technology Co., Ltd
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010-82967028 13522913783
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Sinopharm Chemical Reagent Co,Ltd.
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Dalian Meilun Biotech Co., Ltd.
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0411-62910999 13889544652
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Guangzhou Isun Pharmaceutical Co., Ltd
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020-39119399 18927568969
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Nanjing Sunlida Biological Technology Co., Ltd.
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025-57798810
Email
sales@sunlidabio.com
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