PantoprazoleSodiumSesquihydrate
PantoprazoleSodiumSesquihydrate Basic information
- Product Name:
- PantoprazoleSodiumSesquihydrate
- Synonyms:
-
- Pantoprazole sodium hydrate
- 1H-Benzimidazole, 5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl)sulfinyl)-, sodium salt, hydrate (2:3)
- Unii-6871619Q5x
- 6-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt hydrate (2:2:3)
- SKF-96022 SODIUM HYDRATE
- Pantoprazole sodium sesquihydrate CRS
- Pantoprazole for system suitability CRS
- BY1023 (sodium hydrate)
- CAS:
- 164579-32-2
- MF:
- C16H18F2N3NaO5S
- MW:
- 425.38
- EINECS:
- 1312995-182-4
- Mol File:
- 164579-32-2.mol
PantoprazoleSodiumSesquihydrate Chemical Properties
- storage temp.
- 4°C, protect from light
- solubility
- Freely soluble in water and in ethanol (96 per cent), practically insoluble in hexane.
- form
- Solid
- color
- White to off-white
PantoprazoleSodiumSesquihydrate Usage And Synthesis
Chemical Properties
White or almost white powder.
Uses
Pantoprazole Sodium Hydrate is a metabolite of Pantoprazole Sodium Salt which is an antiulcerative. Gastric pump inhibitor. The free acid, Pantoprazole is a prodrug used in the treatment of acid related disorders and Helicobacter pylori infections.
Uses
Treatment of various acid-related gastrointestinal diseases, including acute erosive esophagitishealing and maintenance, treatment of hypersecretory conditions, Zollinger-Ellison Syndrome (ZES), and eradication of Helicobacter pylori infection.
brand name
Protonix (Wyeth).
in vivo
Pantoprazole sodium hydrate (BY1023 sodium hydrate; 200 mg/kg; IP; once a week for 3 weeks) significantly increases tumor growth delay of MCF-7 xenografts combined with Doxorubicin[1].
Pantoprazole sodium hydrate (0.3-3 mg/kg, p.o.) dose-dependently decreases both basal acid secretion in pylorus-ligated rats and the stimulated acid secretion induced by mepirizole in acute fistula rats[4].
| Animal Model: | Mice bearing MCF-7 or A431 xenografts[1] |
| Dosage: | 200 mg/kg |
| Administration: | IP; once a week for 3 weeks; alone or 2 hours before Doxorubicin (6 mg/kg i.v.) |
| Result: | Showed even greater growth delay of MCF-7 xenografts with Doxorubicin compared with the single-dose combination. Significantly increased tumor growth delay with a single dose with Doxorubicin. There is no effect on growth delay alone. |
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PantoprazoleSodiumSesquihydrate(164579-32-2)Related Product Information
- PANTOPRAZOLE N-OXIDE
- Pantoprazole Magnesium
- 2-CHLOROMETHYL-3,4-DIMETHOXY PYRIDINE HYDROCHLORIDE
- DesdifluoroMethoxy Hydroxy Pantoprazole
- S-Pantoprazole
- Pantoprazole Impurity 5
- 5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole
- Pantoprazole EP Impurity F
- (+)-(R)-Pantoprazole
- N-[(3,4-DiMethoxy-2-pyridinyl)Methyl] Pantoprazole Sulfide
- PANTOPRAZOLE SODIUM SESQUIHYDRATE
- PANTOPRAZOLE SULFONE N-OXIDE
- Pantoprazole Impurity 11
- 5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole
- 2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d] imidazol-5-ol
- N-Methyl Pantoprazole, mixture of 1 and 3 isomers
- 3-(2'-DEOXY-BETA-D-2-RIBOFURANOSYL)PYRIDO[2,3-D]PYRIMIDINE-2,7(8H)-DIONE
- Pantoprazole Sodium