trans-(-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamidehydrochloride
trans-(-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamidehydrochloride Basic information
- Product Name:
- trans-(-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamidehydrochloride
- Synonyms:
-
- N-Methyl-N-[2α-(1-pyrrolidinyl)cyclohexan-1β-yl]-3,4-dichlorophenylacetamide
- (+/-)-trans-U-50488
- U50,488
- 2-(3,4-dichlorophenyl)-N-methyl-N-(2-pyrrolidin-1-ylcyclohexyl)acetami de
- trans-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide mesylate
- rel-3,4-Dichloro-N-methyl-N-[(1α*)-2β*-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide
- 3,4-Dichloro-N-methyl-N-[(1β,2α)-2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide
- 3,4-Dichloro-N-methyl-N-[2α-(pyrrolidin-1-yl)cyclohexan-1β-yl]benzeneacetamide
- CAS:
- 67198-13-4
- MF:
- C19H26Cl2N2O
- MW:
- 369.33
- Product Categories:
-
- Opioid receptor and opioid-like receptor
- Mol File:
- 67198-13-4.mol
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trans-(-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamidehydrochloride Chemical Properties
- Melting point:
- 204-208℃
- RTECS
- CY1484710
- storage temp.
- Desiccate at RT
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trans-(-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamidehydrochloride Usage And Synthesis
Uses
U 50488 is a selective κ-opioid agonist with analgesic, diuretic, and antitussive properties. κ-opioid agonists are useful compounds to elucidate the functions of κ-receptors in the central nervous system.
Definition
ChEBI: A monocarboxylic acid amide obtained by formal condensation between the carboxy group of 3,4-dichlorophenylacetic acid and the secondary amino group of (1R,2R)-N-methyl-2-(pyrrolidin-1-yl)cyclohexanamine
Biological Activity
Selective κ -opioid agonist. At higher concentrations blocks Na + channels. See separate isomers (trans-(-)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride and 0471 ).
trans-(-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamidehydrochlorideSupplier
3B Pharmachem (Wuhan) International Co.,Ltd.
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- 821-50328103-801 18930552037
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Shanghai Synchem Pharma Co., ltd
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EMMX Biotechnology LLC
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Hebei Binshare New Material Co. Ltd
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Shanghai Universal Biotech Co.,Ltd
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- 18768175414
- gaojun@univ-bio.com
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trans-(-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamidehydrochloride(67198-13-4)Related Product Information
- (+)-U-50488 HYDROCHLORIDE
- trans-(-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamidehydrochloride
- (-)-(1S,2R)-CIS-3,4-DICHLORO-N-METHYL-N-[2-(1-PYRROLIDINYL)-CYCLOHEXYL]-BENZENEACETAMIDE TARTRATE
- (+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE