Safrazine
Safrazine Basic information
- Product Name:
- Safrazine
- Synonyms:
-
- Safrazine
- 1-[3-(1,3-Benzodioxol-5-yl)-1-methylpropyl]hydrazine
- Safrasine
- Saphrazine
- 4-(1,3-benzodioxol-5-yl)butan-2-ylhydrazine
- CAS:
- 33419-68-0
- MF:
- C11H16N2O2
- MW:
- 208.25694
- Mol File:
- 33419-68-0.mol
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Safrazine Chemical Properties
- Boiling point:
- 347.46°C (rough estimate)
- Density
- 1.1123 (rough estimate)
- refractive index
- 1.5000 (estimate)
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Safrazine Usage And Synthesis
Uses
Safrazine is an irreversible, non-specific and orally active monoamine oxidase (MAO) inhibitor. Safrazine can be used for the research of depression[1].
in vivo
Safrazine (oral; 3, 10, 30 mg/kg) causes the increases contents of monoamine lasted for at least 24 h[1].
Safrazine strongly inhibits both 5-HT and PEA deaminations, but shows no selectivity toward the substrate used[1].
| Animal Model: | Male ddY mice[1] |
| Dosage: | 3, 10, 30 mg/kg |
| Administration: | Oral |
| Result: | Inhibited significantly both 5-HT and PEA deaminations at only 3 mg/kg by 77% and 71%, respectively. Completely reduced both deaminations at 10 and 30 mg/kg and not observed specificity toward substrates. |
References
[1] T Yokoyama, et al. Comparative studies of the effects of RS-8359 and safrazine on monoamine oxidase in-vitro and in-vivo in mouse brain. J Pharm Pharmacol. 1989 Jan;41(1):32-6. DOI:10.1111/j.2042-7158.1989.tb06324.x