D-gamma-Tocotrienol
D-gamma-Tocotrienol Basic information
- Product Name:
- D-gamma-Tocotrienol
- Synonyms:
-
- 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-tr imethyl-3,7,11-tridecatrienyl]-, (2R)- (9CI)
- D-G-TOCOTRIENOL
- (R-(all-E))-3,4-Dihydro-2,7,8-trimethyl-2-(4,8,12,16,20,24,28,32-octamethyl-3,7,11,15,19,23,27,31-tritriacontaoctaenyl)-2H-1-benzopyran-6-ol
- (2R)-2β,7,8-Trimethyl-2-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-3,4-dihydro-2H-1-benzopyran-6-ol
- (R)-3,4-Dihydro-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-2H-1-benzopyran-6-ol
- (R-(E,E))-3,4-Dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2H-1-benzopyran-6-ol
- (R)-gamma-Tocotrienol
- 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-, [R-(E,E)]-
- CAS:
- 14101-61-2
- MF:
- C28H42O2
- MW:
- 410.63
- Mol File:
- 14101-61-2.mol
D-gamma-Tocotrienol Chemical Properties
- Boiling point:
- 530.8±49.0 °C(Predicted)
- Density
- 0.964±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- form
- Liquid
- pka
- 11.05±0.40(Predicted)
- color
- Very Dark Yellow
- Stability:
- Light Sensitive
- LogP
- 10.300 (est)
D-gamma-Tocotrienol Usage And Synthesis
Description
γ-Tocotrienol is a form of vitamin E that has been found in rice bran and has diverse biological activities. It reduces cell death induced by hydrogen peroxide, paraquat, S-nitrocysteine, SIN-1 , or L-buthionine-(S,R)-sulfoximine (BSO; ) in rat striatal cultures when used at concentrations ranging from 0.1 to 10 μM. γ-Tocotrienol (20 μM) induces apoptosis in malignant sympathoadrenal (+SA) mouse mammary epithelial cells. In vivo, γ-tocotrienol (15, 30, and 150 mg/kg) reduces blood pressure and plasma lipid peroxide levels in spontaneously hypertensive rats. [Matreya, LLC. Catalog No. 2111]
Chemical Properties
g:d:aTocotrienol 1.6:0.4:1
Uses
γ-Tocotrienol exhibits antioxidant properties and belongs to the vitamin E family. It is naturally found in wheat germ oil and bran. In addition, α-tocopherol and γ-tocotrienol derivatives are potential lead compounds for developing?anticancer and?antiproliferative agents against?MCF-7 and MDA-MB-231 breast cancer cells and the A549 lung cancer cells.
Definition
ChEBI: A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2, 7 and 8 and a farnesyl chain at position 2.
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