PD 145065 Chemical Properties

storage temp. 

−20°C

solubility 

phosphate buffer, pH 7.5: 1mg/mL

form 

White solid

color 

white

Sequence

Ac-{D-Bhg}-Leu-Asp-Ile-Ile-Trp-OH (Bhg = 5H-dibenzo[a,d]cycloheptene-5-glycine)

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

PD 145065 Usage And Synthesis

Uses

PD 145065 is a highly potent but non-selective endothelin receptor antagonist with an IC50 value of 4 nM for the ETA receptor for rabbit renal artery vascular smooth muscle cells[1].

Biological Activity

Cell permeable: no', 'Primary Target
Endothelin receptor antagonist', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 4 nM against endothelin receptor (ETA receptor) in rabbit renal artery vascular smooth muscle cells; 15 nM for the ETB receptor (r at cerebellum)

References

[1] Warner TD, et al. Reversal of established responses to endothelin-1 in vivo and in vitro by the endothelin receptor antagonists, BQ-123 and PD 145065. Br J Pharmacol. 1994 May;112(1):207-13. DOI:10.1111/j.1476-5381.1994.tb13053.x

PD 145065(153049-49-1)Related Product Information

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