4-Pyridinemethanol,2-methoxy-(9CI) Chemical Properties

Boiling point:

259.2±25.0 °C(Predicted)

Density 

1.155±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

liquid

pka

13.19±0.10(Predicted)

color 

Colourless to light yellow

Safety Information

HazardClass 

IRRITANT

HS Code 

2933399990

4-Pyridinemethanol,2-methoxy-(9CI) Usage And Synthesis

Synthesis

The general procedure for the synthesis of 2-methoxypyridine-4-methanol (Ref. Compound No. 9-1) from 2-methoxypyridine-4-methylmethoxymethyl ether (Ref. Compound No. 8-1) is as follows: to 2-methoxypyridine-4-methylmethoxymethyl ether (4.2 g) was added a solution of ethyl acetate with 4 N HCl (11 mL, 44 mmol) under cooling in an ice bath The reaction mixture was stirred for 30 min. Subsequently, the reaction mixture was diluted with chloroform (100 mL) and washed twice with saturated aqueous sodium bicarbonate solution (50 mL). The organic layer was dried with anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure to give 0.69 g of the title compound as a yellow oil in 99% yield. The product was characterized by 1H-NMR (500 MHz, CDCl3): δ 1.89 (s, 1H), 3.94 (s, 3H), 4.69 (d, J = 4.3 Hz, 2H), 6.75 (s, 1H), 6.85 (d, J = 5.2 Hz, 1H), 8.12 (d, J = 5.2 Hz, 1H).

References

[1] Patent: EP1602647, 2005, A1. Location in patent: Page/Page column 51

4-Pyridinemethanol,2-methoxy-(9CI)(123148-66-3)Related Product Information

• 2-ETHOXY-4-PYRIDINECARBOXYLIC ACID
• 2-Methoxy-4-pyridinecarboxylic acid
• 2-Chloro-6-methoxyisonicotinic acid
• 5-AMINO-2-METHOXY-ISONICOTINIC ACID
• 2-(2,2,2-Trifluoroethoxy)-4-pyridinecarboxylicacid
• 4-Pyridinemethanol,2-methoxy-(9CI)
• 3-Amino-2-methoxy-6-methyl-4-pyridinecarboxylicacidethylester
• METHYL 2-CHLORO-6-METHOXYPYRIDINE-4-CARBOXYLATE
• 2-METHOXY-QUINOLINE-4-CARBOXYLIC ACID
• 2-Methoxy-6-methyl-4-pyridinecarboxylicacidethylester
• 4-(CYANOMETHYL)PHENYL 2-CHLORO-6-METHOXYISONICOTINATE
• RARECHEM AL BO 1900
• RARECHEM AL BW 1651
• 2-BENZYLOXY-6-CHLORO-ISONICOTINIC ACID
• RARECHEM AL BO 1902
• RARECHEM AL BO 2182
• 2-CHLORO-4-[(([(3-CHLORO-4-FLUOROPHENYL)METHYLENE]AMINO)OXY)CARBONYL]-6-METHOXYPYRIDINE
• RARECHEM AL BO 1901