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Rimonabant hydrochloride

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Rimonabant hydrochloride Basic information

Product Name:
Rimonabant hydrochloride
Synonyms:
  • RIMONABANT HYDROCHLORIDE
  • 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-n-1-piperidinyl-1h-pyrazole-3-carboxamide monohydrochloride
  • ACOMPLIA
  • ACOMPLIA (RIMONABANT
  • RIMONABANT HCL
  • Rimonabant(Acomplia)
  • RimonabantConsultedStandard
  • Acomplia, SR141716
CAS:
158681-13-1
MF:
C22H21Cl3N4O.ClH
MW:
500.25
EINECS:
233-720-0
Product Categories:
  • SR141716
  • Aromatics
  • Cnbio
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Heterocycles
  • API
  • Pharmaceuticals
Mol File:
158681-13-1.mol
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Rimonabant hydrochloride Chemical Properties

Melting point:
230-240°C
storage temp. 
2-8°C
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
color 
white to beige
CAS DataBase Reference
158681-13-1(CAS DataBase Reference)
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Safety Information

Hazard Codes 
T,Xi
Risk Statements 
25-36
Safety Statements 
26-45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
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Rimonabant hydrochloride Usage And Synthesis

Chemical Properties

White to Off-White Crystalline Solid

Uses

The first of a new class of selective (Cannabinoid-1 (CB-1) receptor antagonists

Uses

A brain cannabinoid receptor (CB1) antagonist. Antiobesity agent.

Uses

Rimonabant hydrochloride has been used as an antagonist of cannabinoid 1 (CB1) receptor:

  • to study its effects on protein synthesis in C2C12 myotubes
  • to analyze its effects on human astroglia
  • in combination with methanandamide (mAEA) to study its effects on murine gastric vagal afferent mechanosensitivity

Hazard

A poison.

Biochem/physiol Actions

Rimonabant acts as a mycobacterial membrane protein large 3 (MMPL3) inhibitor. Rimonabant hydrochloride exhibits therapeutic activity against weight reduction and smoking cessation.

storage

Desiccate at RT

Rimonabant hydrochlorideSupplier

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