CGS 25155
CGS 25155 Basic information
- Product Name:
- CGS 25155
- Synonyms:
-
- CGS 25155
- L-Proline, 1-[[(2S,9R)-9-[(acetylthio)methyl]decahydro-10-oxo-2-azecinyl]carbonyl]-4-hydroxy-, phenylmethyl ester, (4R)-
- CAS:
- 150126-87-7
- MF:
- C25H34N2O6S
- MW:
- 490.61
- Mol File:
- 150126-87-7.mol
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CGS 25155 Chemical Properties
- Boiling point:
- 725.0±60.0 °C(Predicted)
- Density
- 1.234±0.06 g/cm3(Predicted)
- pka
- 14.01±0.40(Predicted)
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CGS 25155 Usage And Synthesis
Description
Cgs 25155 is an orally active NEP 24.11 inhibitor.
Uses
CGS25155 is an orally active neutral endopeptidase 24.11 (NEP 24.11) inhibitor with an IC50 of 3 nM. CGS25155 can slow down the degradation of the cardiac hormone atrial natriuretic peptide (ANP) and exhibits antihypertensive activity in the DOCA-salt induced rat hypertension model. CGS25155 can be used in cardiovascular disease research[1].
References
[1] MacPherson LJ, et al. Design and synthesis of an orally active macrocyclic neutral endopeptidase 24.11 inhibitor. J Med Chem. 1993 Nov 26;36(24):3821-8. DOI:10.1021/jm00076a009