fibrostatin C Usage And Synthesis

Description

Fibrostatin C is a prolyl 4-hydroxylase (PH) inhibitor produced by Streptomyces catenulae subsp. griseospora.

Uses

Fibrostatin C (P-23924C) is an orally active prolyl hydroxylase inhibitor that also inhibits collagen biosynthesis. Fibrostatin C also increases the number of cytoplasmic granules immunoreactive with antibodies to collagen I or III. Fibrostatin C inhibits the secretion of type I collagen in Tenon's capsule fibroblasts. Fibrostatin C is promising for research of the wound fibrotic response in the wound of glaucoma filtering surgery[1][2].

References

[1] Ishimaru T, et al. Inhibition of prolyl hydroxylase activity and collagen biosynthesis by fibrostatin C, a novel inhibitor produced by Streptomyces catenulae subsp. griseospora No. 23924. J Antibiot (Tokyo). 1988 Nov;41(11):1668-74. DOI:10.7164/antibiotics.41.1668
[2] Saika S, et al. Effect of fibrostatin C, an inhibitor of prolyl 4-hydroxylase, on collagen secretion by human Tenon's capsule fibroblasts in vitro. Graefes Arch Clin Exp Ophthalmol. 1996 Aug;234 Suppl 1:S214-22. DOI:10.1007/BF02343075

fibrostatin C(91776-47-5)Related Product Information

• 2-METHOXY-1,4-NAPHTHOQUINONE
• 2-Hydroxy-1,4-naphoquinone
• N-ACETYL-S-BENZYL-DL-CYSTEINE
• 4-METHYL-2-[(METHYLTHIO)METHYL]PHENOL
• 2-hydroxyjuglone
• 1,4-DIHYDRO-2,7-DIMETHOXYNAPHTHALENE
• 2,5-DIMETHYL-P-ANISALDEHYDE
• N-ACETYL-S-BENZYL-L-CYSTEINE
• S-P-METHYLBENZYL-L-CYSTEINE
• H-CYS(CH3BZL)-OL
• fibrostatin C