glucopiericidin A Usage And Synthesis

Uses

Glucopiericidin A is a natural piericidin compound obtained from a marine-derived Streptomyces strain. Glucopiericidin A serves as a glucose transporter (GLUT) chemical probe and suppresses glycolysis. Glucopiericidin A inhibits ATP-dependent filopodia protrusion with Piericidin A (PA; HY-114936) and has no effect alone. Glucopiericidin A induces cell apoptosis through reducing the reactive oxygen species (ROS) level by increasing PRDX1 and exhibits potent antitumor efficacy in ACHN mice xenografts[1][2].

in vivo

References

[1] Mitsuhiro Kitagawa, et al. Metabolomic identification of the target of the filopodia protrusion inhibitor glucopiericidin A. Chem Biol. 2010 Sep 24;17(9):989-98. DOI:10.1016/j.chembiol.2010.06.017
[2] Xuefeng Zhou, et al. Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1. J Med Chem. 2019 Aug 8;62(15):7058-7069. DOI:10.1021/acs.jmedchem.9b00598

glucopiericidin A(108073-65-0)Related Product Information

• 2,3-Dimethoxypyridine
• 3,4-Dihydroxypyridine
• 2,4-DIHYDROXY-6-METHYLPYRIDINE
• 4-Hydroxy-2,3-dimethoxypyridine
• 2-METHOXY-5-PICOLINE
• 2(1H)-Pyridinone,4-hydroxy-5-methyl-(9CI)
• 5,7-OCTADIEN-2-OL, 2,6-DIMETHYL
• 2,3-Dihydroxypyridine
• glucopiericidin A