ChemicalBook > Product Catalog > Organic Chemistry > Spirocyclic Compounds > 1-Methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-1,2-dihydroquinoline-3-carboxamide
1-Methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-1,2-dihydroquinoline-3-carboxamide
1-Methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-1,2-dihydroquinoline-3-carboxamide Basic information
- Product Name:
- 1-Methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-1,2-dihydroquinoline-3-carboxamide
- Synonyms:
-
- 1-Methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-1,2-dihydroquinoline-3-carboxamide
- DGKα-IN-3
- 3-Quinolinecarboxamide, 1,2-dihydro-1-methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]dec-8-yl]-
- CAS:
- 2648418-86-2
- MF:
- C26H27F3N4O3
- MW:
- 500.51
- Mol File:
- 2648418-86-2.mol
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1-Methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-1,2-dihydroquinoline-3-carboxamide Chemical Properties
- Boiling point:
- 634.854±55.00 °C(Press: 760.00 Torr)(predicted)
- Density
- 1.423±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
- pka
- 14.711±0.20(predicted)
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1-Methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-1,2-dihydroquinoline-3-carboxamide Usage And Synthesis
Uses
DGKα-IN-3 (example 25) is a DGKα inhibitor with the IC50 of 283 nM, extracted from patent WO2021105115. DGKα-IN-2 significantly enhances the anti-tumor effect of anti-PD-1 by increasing the proliferation and function of T cells. DGKα-IN-2 has the potential for cancer and immunology study.
References
[1] Schmees, Norbert, et al. Preparation of substituted aminoquinolones as DGKα inhibitors for immune activation. WO2021105115.