1,2,3,4,5,6,7,8,9-NONACHLORODECANE
1,2,3,4,5,6,7,8,9-NONACHLORODECANE Basic information
- Product Name:
- 1,2,3,4,5,6,7,8,9-NONACHLORODECANE
- Synonyms:
-
- CP-10
- 1,2,3,4,5,6,7,8,9-NONACHLORODECANE
- 1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-[4-[[4-[6-[(6-acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]methyl]-1H-1,2,3-triazol-1-yl]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
- 4-((2-(2-(4-((4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
- 4-[(2-{2-[4-({4-[6-({6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7H,8H-pyrido[2,3-d]pyrimidin-2-yl}amino)pyridin-3-yl]piperazin-1-yl}methyl)-1H-1,2,3-triazol-1-yl]ethoxy}ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
- CAS:
- 2366268-80-4
- MF:
- C44H49N13O7
- MW:
- 871.94
- Mol File:
- Mol File
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1,2,3,4,5,6,7,8,9-NONACHLORODECANE Chemical Properties
- Density
- 1.55±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 200 mg/mL (229.37 mM)
- form
- Solid
- pka
- 10.74±0.40(Predicted)
- color
- Light yellow to yellow
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1,2,3,4,5,6,7,8,9-NONACHLORODECANE Usage And Synthesis
Uses
CP-10 is a PROTAC connected by ligands for Cereblon and CDK, with highly selective, specific, and remarkable CDK6 degradation (DC50=2.1 nM). It inhibits proliferation of several haematopoietic cancer cells with impressive potency including multiple myeloma, and can still degrades mutated and overexpressed CDK6[1].
IC 50
CDK6: 2.1 nM (DC50); Cereblon
References
[1] Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 2. DOI:10.1021/acs.jmedchem.9b00871
1,2,3,4,5,6,7,8,9-NONACHLORODECANESupplier
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