8-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione
8-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione Basic information
- Product Name:
- 8-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione
- Synonyms:
-
- 8-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione
- 8-[2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl]-3,7-dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
- 1H-Purine-2,6-dione, 8-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl]-3,9-dihydro-1-methyl-3-(2-methylpropyl)-
- CAS:
- 90749-32-9
- MF:
- C29H36N6O2
- MW:
- 500.64
- Mol File:
- 90749-32-9.mol
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8-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione Chemical Properties
- Melting point:
- 202 °C(Solv: ethyl acetate (141-78-6))
- Boiling point:
- 692.5±65.0 °C(Predicted)
- Density
- 1.210±0.06 g/cm3(Predicted)
- pka
- 8.99±0.70(Predicted)
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8-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione Usage And Synthesis
Uses
Laprafylline (S 9795), a xanthine derivative, is a bronchodilator. Laprafylline has potent anti-bronchoconstrictive effects, inhibiting action on mast cell degranulation and phosphodiesterase (PDE) activity (IC50 of 6 μM)[1].
in vivo
In male Sprague Dawley rats, Laprafylline (S 9795; 2.5-10mg/kg; iv) disappears rapidly from plasma with an elimination t1/2 of 0.8 h, regardless of the dose administered. The volume of distribution is high (about 3 L/kg) but total clearance is also high (about 40 mL/min/kg).
References
[1] G Bianchi, et al. Kinetics and brain uptake of S 9795, a new xanthine derivate, in rats. Eur J Drug Metab Pharmacokinet. 1989 Jul-Sep;14(3):201-8. DOI:10.1007/BF03190100
8-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dioneSupplier
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