ENPROFYLLINE
ENPROFYLLINE Basic information
- Product Name:
- ENPROFYLLINE
- Synonyms:
-
- 3-Propylxanthfine
- Enprofyllilie
- 3-propyl-7H-purine-2,6-dione
- 3-propyl-7H-purine-2,6-quinone
- 1H-Purine-2,6-dione, 3,9-dihydro-3-propyl-
- ENPROPHYLLINE
- 3-Propyl-1H-purine-2,6(3H,7H)-dione
- 3-N-PROPYLXANTHINE
- CAS:
- 41078-02-8
- MF:
- C8H10N4O2
- MW:
- 194.19
- EINECS:
- 255-201-8
- Mol File:
- 41078-02-8.mol
ENPROFYLLINE Chemical Properties
- Melting point:
- 287-289 °C
- Density
- 1.38 g/cm3
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble
- form
- solid
- pka
- 10.26±0.20(Predicted)
- color
- white
- CAS DataBase Reference
- 41078-02-8
MSDS
- Language:English Provider:SigmaAldrich
ENPROFYLLINE Usage And Synthesis
Description
3-Propylxanthine is a xanthine derivative that antagonizes adenosine receptors (Kis = 44, 32, and 6.3 μM for A1, A2A, and A2B, respectively) and cAMP phosphodiesterase (Ki = 42 μM). Through these actions, 3-propylxanthine induces smooth muscle relaxation, blocks smooth muscle contraction and VEGF secretion driven by adenosine receptor agonists, and reduces bronchial hyperresponsiveness.
Uses
Bronchodilator.
Uses
Enprofylline is a xanthine lacking adenosine receptor antagonism.
Definition
ChEBI: Xanthine bearing a propyl substituent at position 3. A bronchodilator, it is used for the symptomatic treatment of asthma and chronic obstructive pulmonary disease, and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic n uropathy.
in vivo
Enprofylline increases heart rate (HR). Injection of Enprofylline (7.5 and 30 mg/kg) increases HR in male WT mouse from 529±23 to 590±20 and 562±20 after the low and high dose, respectively[3].
A high dose of Enprofylline (30 mg/kg) also decreases temperature compared with saline injection in female (but not in males) WT mice, but a low dose (7.5 mg/kg) has little effect on mouse temperature[3].
| Animal Model: | A1RKO mice (were cross-bred to C57BL/6 mice for six generations) and A2ARKO mice (were backcrossed to C57BL/6 mice for more than 10 generations)[3] |
| Dosage: | 30 mg/kg |
| Administration: | Intraperitoneally injected (bolus) at 2-h intervals |
| Result: | Increased HR in male WT mouse from 529±23 to 590±20 and 562±20 after the low (7.5 mg/kg) and high dose (30 mg/kg), respectively. |
IC 50
A2B receptor: 7 μM (Ki)
References
[1] J LINDEN. Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells.[J]. Molecular Pharmacology, 1999, 56 4: 705-713.
[2] K. OGAWA T. S K Takagi. Mechanism of xanthine-induced relaxation of guinea-pig isolated trachealis muscle[J]. British Journal of Pharmacology, 1989, 97 2: 542-546. DOI: 10.1111/j.1476-5381.1989.tb11983.x
[3] U SCHWABE M J L D Ukena. Xanthine derivatives as antagonists at A1 and A2 adenosine receptors.[J]. Naunyn-Schmiedeberg’s archives of pharmacology, 1985, 330 3: 212-221. DOI: 10.1007/bf00572436
[4] BIRGITTE H?IER. Contraction-induced secretion of VEGF from skeletal muscle cells is mediated by adenosine.[J]. American journal of physiology. Heart and circulatory physiology, 2010: H857-62. DOI: 10.1152/ajpheart.00082.2010
[5] G H KO?TER. Effect of theophylline and enprofylline on bronchial hyperresponsiveness.[J]. Thorax, 1989, 44 12: 1022-1026. DOI: 10.1136/thx.44.12.1022
ENPROFYLLINESupplier
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- 1-(800)-881-8210
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- 010-56205725
- waley188@sohu.com
- Tel
- 027-87465837 19945049750
- sales@finetechnology-ind.com
ENPROFYLLINE(41078-02-8)Related Product Information
- 1,3-DIPROPYL-8-P-SULFOPHENYLXANTHINE
- 3-ISOBUTYL-1-METHYLXANTHINE
- ENPROFYLLINE
- Cipamfylline
- 1,3-Dipropyl-7-methylxanthine
- Verofylline
- Denbufylline
- 1,3-DI-N-BUTYLXANTHINE
- CPX, [DIPROPYL-2,3-3H]
- 8-METHOXYMETHYL-3-ISOBUTYL-1-METHYLXANTHINE
- 8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE
- 1,3-DIPROPYL-8-PHENYLXANTHINE
- 8-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione
- XANTHINE AMINE CONGENER
- Mexafylline
- CYCLOPENTYL-1,3-DIPROPYLXANTHINE, 8-[DIPROPYL-2,3-3H(N)]-
- 1,3-DIPROPYL-8-(2-AMINO-4-CHLOROPHENYL)-XANTHINE
- 1,3-Diisobutyl-8-methylxanthine