5,7-Dichloroimidazo[4,5-b]pyridine Chemical Properties

Melting point:

273-274 °C

Boiling point:

200.8±50.0 °C(Predicted)

Density 

1.79±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

5.37±0.40(Predicted)

Appearance

Off-white to pink Solid

InChI

InChI=1S/C6H3Cl2N3/c7-3-1-4(8)11-6-5(3)9-2-10-6/h1-2H,(H,9,10,11)

InChIKey

IKJFWUNKUZVHGU-UHFFFAOYSA-N

SMILES

C12NC=NC1=C(Cl)C=C(Cl)N=2

Safety Information

HS Code 

2933998090

5,7-Dichloroimidazo[4,5-b]pyridine Usage And Synthesis

Uses

5,7-Dichloro-1H-imidazo[4,5-B]pyridine is an important type of imidazopyridine compound with good antimicrobial and bactericidal effects.

Synthesis

General procedure for the synthesis of 5,7-dichloro-1H-imidazo[4,5-B]pyridine from 7-nitro-3H-imidazo[4,5-B]pyridine 4-oxide: 7-nitro-1H-imidazo[4,5-b]pyridine 4-oxide (2.0 g, 11.04 mmol) was added batchwise to a mixed solution of ice-bath-cooled (0 °C) phosphoryl chloride (POCl3, 30 mL , 322 mmol) and N,N-dimethylformamide (DMF, 15 mL) in a mixed solution. Subsequently, the reaction mixture was heated to 120°C and maintained for 3 hours. After completion of the reaction, it was cooled to room temperature, slowly poured into ice water and neutralized with 5 M sodium hydroxide solution. The reaction mixture was extracted with ethyl acetate (3 × 75 mL). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford the crude product 5,7-dichloro-3H-imidazo[4,5-b]pyridine (1.86 g, 9.89 mmol, 90% yield), which was used directly in the next reaction without further purification. Mass spectrum (electrospray ionization) m/e 188 ([M+H]+). 1H NMR (400 MHz, methanol-d4) δ 8.45 (broad single peak, 1H), 7.46 (single peak, 1H).

References

[1] Patent: WO2013/95761, 2013, A1. Location in patent: Page/Page column 32; 33; 34
[2] Journal of Heterocyclic Chemistry, 1980, vol. 17, # 8, p. 1757 - 1760
[3] Journal of Heterocyclic Chemistry, 1980, vol. 17, # 8, p. 1757 - 1760

5,7-Dichloroimidazo[4,5-b]pyridine(24485-01-6)Related Product Information

• 5,7-Dichloroimidazo[4,5-b]pyridine
• 7-Chloro-1H-imidazo[4,5-c]pyridine