1-Isopropylpyrazole Chemical Properties

Boiling point:

143 °C

Density 

0.96

refractive index 

1.4620 to 1.4660

Flash point:

43 °C

storage temp. 

Sealed in dry,Room Temperature

form 

clear liquid

pka

2.29±0.10(Predicted)

color 

Colorless to Almost colorless

Safety Information

RIDADR 

UN 1993 3/PG III

HazardClass 

3

PackingGroup 

III

HS Code 

2933199090

1-Isopropylpyrazole Usage And Synthesis

Synthesis

The reaction mixture was stirred at 120 °C for 90 h with pyrazole (5 g, 73.44 mmol) and 2-bromopropane (15 mL, 2 eq.), NaHCO3 (12.2 g, 2 eq.) was added as base. During the reaction, 2-bromopropane was supplemented as needed to maintain the reaction volume. Upon completion of the reaction, the insoluble solids were removed by filtration and the filtrate was purified by distillation. The colorless syrupy product 1-isopropyl-1H-pyrazole (4.6 g, 57% yield) with a boiling point of 148°C was collected.

References

[1] Patent: WO2006/108591, 2006, A1. Location in patent: Page/Page column 112
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 5, p. 1923 - 1936
[3] Patent: WO2005/12254, 2005, A1. Location in patent: Page/Page column 129
[4] Patent: US2009/170873, 2009, A1. Location in patent: Page/Page column 48

1-Isopropylpyrazole(18952-87-9)Related Product Information

• ISOPROPYL LAURATE
• Pyrazole
• Isopropyl alcohol
• 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
• Pyraclostrobin
• Zolpidem tartrate
• 2,2'-Thiobispropane
• Zolpidem
• 1-(TERT-BUTYL)-3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID
• 5-AMINO-1-(T-BUTYL)PYRAZOLE-4-CARBONITRILE
• 1-(TERT-BUTYL)-3-METHYL-1H-PYRAZOLE-5-CARBONYL CHLORIDE
• 1-(TERT-BUTYL)-3,5-DIMETHYL-1H-PYRAZOLE-4-CARBALDEHYDE
• 2-(3,5-DIMETHYL-4-NITRO-PYRAZOL-1-YL)-PROPIONIC ACID HYDRAZIDE
• 1-(TERT-BUTYL)-3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
• 1-(TERT-BUTYL)-3-METHYL-1H-PYRAZOL-5-YLAMINE
• 2-(3,5-DIMETHYL-4-NITRO-PYRAZOL-1-YL)-PROPIONIC ACID ETHYL ESTER
• 1-Isopropylpyrazole
• 3-[5-AMINO-4-(4-METHOXYPHENYL)-1H-PYRAZOL-1-YL]TETRAHYDRO-1H-1LAMBDA6-THIOPHENE-1,1-DIONE