TRIS SUCCINATE
TRIS SUCCINATE Basic information
- Product Name:
- TRIS SUCCINATE
- Synonyms:
-
- DI[TRIS(HYDROXYMETHYL)AMINOMETHANE] SUCCINATE
- TRIS(HYDROXYMETHYL)AMINOMETHANE SUCCINATE
- TRIS SUCCINATE
- TRIZMA SUCCINATE
- Tris(hydroxymethyl)aminomethane succinate >98%
- Tris-succinate,99%
- 2-AMINO-2-(HYDROXYMETHYL)-1,3-PROPANEDIOL SUCCINATE
- succinic acid, compound with 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:1)
- CAS:
- 84540-64-7
- MF:
- C12H28N2O10
- MW:
- 360.36
- EINECS:
- 283-159-0
- Product Categories:
-
- buffer
- Mol File:
- 84540-64-7.mol
TRIS SUCCINATE Chemical Properties
- Melting point:
- 138-141 °C
Safety Information
- Safety Statements
- 24/25
- HS Code
- 2921490090
MSDS
- Language:English Provider:ACROS
TRIS SUCCINATE Usage And Synthesis
Chemical Properties
White granular or crystalline powder
Uses
Succinic acid tromethamine is a potent and orally active anxiolytic agent. Succinic acid tromethamine is an intermediate product of the tricarboxylic acid cycle. Succinic acid tromethamine can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries[1][2][3].
in vivo
Succinic acid tromethamine (3, 6 mg/kg; p.o.) increases the percentage of entries into open arms and of time spent on open arms in male mice[3].
Succinic acid tromethamine (3, 6, 12 mg/kg; i.p.) significant increases in food intake during 5 min, and 40 min after drug administration rectal temperature was measured, succinic acid at a dose of 1.5 mg/kg, inhibited stress-induced hyperthermia[3].
IC 50
Microbial Metabolite; Human Endogenous Metabolite
References
[1] Zhang YJ, et al. Optimization of succinic acid fermentation with Actinobacillus succinogenes by response surface methodology (RSM). J Zhejiang Univ Sci B. 2012 Feb;13(2):103-10. DOI:10.1631/jzus.B1100134
[2] A T JOHNS, et al. The production of propionic acid by decarboxylation of succinic acid in a bacterial fermentation. Biochem J. 1948;42(1):ii. PMID:18934530
[3] Si Wei Chen, Anxiolytic-like effect of succinic acid in mice. Life Sci. 2003 Nov 7;73(25):3257-64. DOI:10.1016/j.lfs.2003.06.017