1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine Chemical Properties

Boiling point:

125°C (115 mmHg)

Density 

0,98 g/cm³

Flash point:

73°C

storage temp. 

2-8°C

solubility 

Acetone (Sparingly), Chloroform (Sparingly), DMSO (Sparingly), Methanol(Sparingly)

pka

13.42±0.20(Predicted)

form 

Oil

color 

Clear Colourless

Specific Gravity

0.982 (20/4℃)

CAS DataBase Reference

4271-96-9(CAS DataBase Reference)

EPA Substance Registry System

Pyrimidine, 1,4,5,6-tetrahydro-1,2-dimethyl- (4271-96-9)

Safety Information

Hazard Codes 

Xi

Risk Statements 

22-34

Safety Statements 

23-26-36/37/39

RIDADR 

3267

HS Code 

2933599590

1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine Usage And Synthesis

Uses

1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine is a reagent used in the synthesis of pyrantel derivatives with nematocidal activity. Also used as a reactant in the preparation of hapten antibodies that evoke terpenoid cyclization.

Synthesis

General procedure for the synthesis of 1,2-dimethyl-1,4,5,6-tetrahydropyrimidine from N-[3-(methylamino)propyl]-acetamide: N-[3-(methylamino)propyl]-acetamide obtained from the previous step was dissolved in 200 mL of polyphosphoric acid ester (PPE) and placed in a microwave reactor. The reaction temperature was controlled to be 80 °C and the reaction time was 2 hours. After completion of the reaction, the reaction mixture was purified to afford the target product 1,2-dimethyl-1,4,5,6-tetrahydropyrimidine 240 g in 94.42% yield.

References

[1] Patent: CN108822044, 2018, A. Location in patent: Paragraph 0025; 0028; 0031; 0032; 0037; 0042; 0047-0057

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