8-AMINOADENOSINE Chemical Properties

Melting point:

180-185°C dec.

Boiling point:

747.1±70.0 °C(Predicted)

Density 

2.25

storage temp. 

-20°C Freezer

solubility 

H2O: soluble2mg/mL, clear (warmed)

pka

13.07±0.70(Predicted)

form 

powder

color 

white to beige

Water Solubility 

H2O: 2mg/mL, clear (warmed)

InChI

1S/C10H14N6O4/c11-7-4-8(14-2-13-7)16(10(12)15-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,15)(H2,11,13,14)

InChIKey

DVGWFQILDUEEGX-UHFFFAOYSA-N

SMILES

[n]2(c3ncnc(c3nc2N)N)C1OC(C(C1O)O)CO

Safety Information

Hazard Codes 

T

Risk Statements 

25

Safety Statements 

45

RIDADR 

UN 2811 6.1 / PGIII

WGK Germany 

3

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral

8-AMINOADENOSINE Usage And Synthesis

Chemical Properties

Off-White Solid

Uses

The purine nucleoside analog

Biological Activity

8-Aminoadenosine, a ribose nucleoside, reduces cellular ATP levels and inhibits mRNA synthesis. 8-Aminoadenosine also inhibits transcription and polyadenylation. 8-Aminoadenosine potently inhibits varies breast cancer cell lines proliferation and activates cell death independent of p53. 8-NH2-Ado is highly cytotoxic to other cancer cell lines.

IC 50

mTOR

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