3-IODO-7-METHYL (1H)INDAZOLE Chemical Properties

Boiling point:

368.6±22.0 °C(Predicted)

Density 

1.933±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

12.43±0.40(Predicted)

Appearance

White to off-white Solid

3-IODO-7-METHYL (1H)INDAZOLE Usage And Synthesis

Synthesis

7-Methyl-1H-indazole (2 g, 15.15 mmol) was added potassium hydroxide (KOH, 2.12 g, 37.88 mmol) and iodine (I2, 7.7 g, 30.3 mmol) in N,N-dimethylformamide (DMF, 40 mL) and the reaction was stirred at room temperature for 4 hours. After completion of the reaction, the mixture was poured into water (200 mL) and extracted with ethyl acetate (EA, 200 mL). The organic layer was washed sequentially with saturated sodium sulfite solution (100 mL), water (200 mL) and saturated brine (200 mL), dried over anhydrous sodium sulfate (Na2SO4), and concentrated under reduced pressure to afford the target product 3-iodo-7-methyl-1H-indazole (3.6 g, 92% yield) as a yellow solid.

References

[1] Patent: WO2018/132372, 2018, A1. Location in patent: Paragraph 01237
[2] Patent: US2005/54697, 2005, A1. Location in patent: Page/Page column 73

3-IODO-7-METHYL (1H)INDAZOLE(847906-27-8)Related Product Information

• 3-IODO-METHYL [1]INDAZOLE-7-CARBOXYLATE
• 3-IODO-5,7-DIMETHYL (1H)INDAZOLE
• 3-IODO-7-METHYL (1H)INDAZOLE