1,1,2,3-PROPANETETRACARBOXYLIC ACID TETRAETHYL ESTER Chemical Properties

Boiling point:

389.48°C (rough estimate)

Density 

1.1184

refractive index 

1.4380-1.4420

pka

11.42±0.59(Predicted)

form 

clear liquid

color 

Colorless to Almost colorless

InChIKey

WGEVJRBJWMGTSI-UHFFFAOYSA-N

Safety Information

HS Code 

2917.19.7050

1,1,2,3-PROPANETETRACARBOXYLIC ACID TETRAETHYL ESTER Usage And Synthesis

Uses

1,1,2,3-PROPANETETRACARBOXYLIC ACID TETRAETHYL ESTER can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis

Condensation of diethylfumarate and diethylmalonate to propane-1,1,2,3 tetracarboxylate. Catalyst specifications: Catalytic entity: Ph(CH2)-N+(PhmSO3-)3 · EtO- (1 milieq of EtO-), additive:: Sodium meta silicate 1 gm, Support: Charcoal 5 gm, Group IIA metal salt: Barium hydroxide, Method of preparation: Deposition precipitation. Procedure: in a 100-ml flask fitted with an efficient reflux condenser, magnetic stirrer bar and dropping funnel was charged 5 gm of catalyst. With stirring 1.6 g (0.001 mol) diethylmalonate and 25 ml dry ethanol was added. Reaction mixture was warmed and 1.4 gm (0.0081 mol) diethyl fumarate was added. Mixture was refluxed for 8 hours. Reaction mixture was cooled and suspension was centrifuged to recover catalyst. Analysis of reaction liquid indicated 90 % conversion for diethylmalonate. Product was distilled under vacuum 8 mm at 180-190°C to obtain propane-1,1,2,3 tetracarboxylate 85% yield. Catalyst was recovered and washed with ethanol, diethyl ether and dried under vacuum. Catalyst was recycled to obtain equivalent activity.

1,1,2,3-PROPANETETRACARBOXYLIC ACID TETRAETHYL ESTER(635-03-0)Related Product Information

• MONO-METHYL SUCCINATE
• (S)-(-)-Methylsuccinic acid dimethyl ester
• (S)​-2-​methyl-Butanedioic acid-1-​methyl ester
• TRIETHYL 1,1,2-ETHANETRICARBOXYLATE
• Dimethyl isopropylmalonate
• 3-METHYLGLUTARIC ACID
• (R)-(+)-2-METHYLGLUTARIC ACID
• MONOMETHYL 3-METHYLGLUTARATE
• DIETHYL SEC-BUTYLMALONATE
• 2,3-DIMETHYLSUCCINIC ACID
• DIETHYL ISOPROPYLMALONATE
• 2-METHYLGLUTARIC ACID
• (R)-(-)-4-METHYLGLUTARIC ACID 1-MONOMETHYL ESTER
• 1,1,2,3-PROPANETETRACARBOXYLIC ACID TETRAETHYL ESTER
• Dimethyl (R)-(+)-methylsuccinate
• DIMETHYL METHYLSUCCINATE
• (S)-(+)-2-METHYLGLUTARIC ACID
• DIETHYL FORMYLSUCCINATE