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Triisopropylsilane

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Triisopropylsilane Basic information

Product Name:
Triisopropylsilane
Synonyms:
  • Triisopropylsilane(L)
  • Three isopropylsilane
  • Triisopropylsilane 99%
  • Triisopropylsilane Synonyms Triisopropylhydrosilane
  • HandyStep
  • PD-Tips
  • tris(propan-2-yl)silane
  • Triisopropylsilane, 98% 10GR
CAS:
6485-79-6
MF:
C9H22Si
MW:
158.36
EINECS:
464-880-1
Product Categories:
  • Chemical Synthesis
  • Organometallic Reagents
  • Other Reagents
  • Reduction
  • Others
  • Synthetic Reagents
  • Si (Classes of Silicon Compounds)
  • Si-H Compounds
  • Silicon Compounds (for Synthesis)
  • Synthetic Organic Chemistry
  • Alkyl Silanes
  • Hydrogensilanes Hydrogensiloxanes
  • Reducing Agents
  • Biochemics
  • Organometallic Reagents
  • Organosilicon
  • OthersSynthetic Reagents
  • Silanes
  • bc0001
Mol File:
6485-79-6.mol
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Triisopropylsilane Chemical Properties

Boiling point:
84-86 °C/35 mmHg (lit.)
Density 
0.773 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.434(lit.)
Flash point:
99 °F
storage temp. 
Store below +30°C.
solubility 
Benzene (Soluble), Chloroform (Soluble)
form 
liquid
Specific Gravity
0.773
color 
colorless
Water Solubility 
Immiscible with water.
Sensitive 
Moisture Sensitive
Hydrolytic Sensitivity
3: reacts with aqueous base
BRN 
1733718
InChIKey
YDJXDYKQMRNUSA-UHFFFAOYSA-N
CAS DataBase Reference
6485-79-6(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
10-36/37/38
Safety Statements 
26-36-37/39-16
RIDADR 
UN 1993 3/PG 3
WGK Germany 
3
10-21
TSCA 
No
HS Code 
2931 90 00
HazardClass 
3
PackingGroup 
III

MSDS

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Triisopropylsilane Usage And Synthesis

Chemical Properties

Clear colorless liquid

Uses

The bulky isopropyl groups (vs. ethyl) allow for more selective reductions, e.g., beta-selective reduction of anomeric C-phenyl ketals, but do not diminish their activity (e.g. in the copper triflate catalyzed reductive etherification of trimethylsilyl ethers).

Uses

Selective silylation of primary hydroxy groups in the presence of secondary alcohol.

Uses

Triisopropylsilane is used as a protecting group in peptide synthesis and is also used as a reducing agent for the selective reduction of anomeric C-phenyl ketals. It is used in the selective silylation of primary hydroxyl groups without affecting the secondary hydroxyl group. It is used in the preparation of anti-1,2-diols catalyzed by a Ni(O) N-heterocyclic carbine complex with high diastereoselectivity.

Application

Very sterically-hindered silane. Used as a cation scavenger in the deprotection of peptides.

TriisopropylsilaneSupplier

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