Cevimeline Hydrochloride Salt
Cevimeline Hydrochloride Salt Basic information
- Product Name:
- Cevimeline Hydrochloride Salt
- Synonyms:
-
- CEVIMELINE, HYDROCHLORIDE SALT
- Fks 508
- Saligren
- Snd 5008
- cis-2-Methylspiro[1,3-oxathiolane-5,3'-quinuclidine]hydrochloride
- (2'R,3R)-rel-2'-Methyl- spiro[1-azabicyclo[2.2.2]octane-3,5'-[1,3]oxathiolane] hydrochloride
- SNK 508
- CeviMelin
- CAS:
- 107220-28-0
- MF:
- C10H18ClNOS
- MW:
- 235.77402
- Product Categories:
-
- Heterocycles
- Intermediates & Fine Chemicals
- Neurochemicals
- Pharmaceuticals
- API
- Mol File:
- 107220-28-0.mol
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Cevimeline Hydrochloride Salt Chemical Properties
- Melting point:
- 195-197?C
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Water:50.0(Max Conc. mg/mL);212.07(Max Conc. mM)
- form
- A crystalline solid
- color
- White to off-white
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C10H17NOS.ClH/c1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11;/h8-9H,2-7H2,1H3;1H
- InChIKey
- SURWTGAXEIEOGY-UHFFFAOYSA-N
- SMILES
- C1CC2C3(CSC(C)O3)CN1CC2.Cl
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Cevimeline Hydrochloride Salt Usage And Synthesis
Chemical Properties
Off-White Solid
Uses
A novel muscarinic M1 and M3 receptor agonist. Sialagogue.
Biological Activity
Selective M 1 receptor agonist. Induces atropine-sensitive contractions of isolated guinea pig ilea and trachea preparations (EC 50 values are 3.5 and 3 μ M respectively). Reverses AF64A-induced cognitive impairments in vivo .
in vivo
Cevimeline (0.008-0.016 mg/kg; intraperitoneal injection; male Wistar rats) treatment shows slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response. Cevimeline inhibits angiotensin II-induced water intake and neuronal activity in the subfornical organ at 0.016 mg/kg[1].
| Animal Model: | Male Wistar rats (8-week-old) injected with angiotensin-II[1] |
| Dosage: | 0.008 mg/kg, 0.016 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Showed slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response. |
IC 50
mAChR1; mAChR3
storage
-20°C
Cevimeline Hydrochloride SaltSupplier
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