Cevimeline Hydrochloride Salt

Product Name: Cevimeline Hydrochloride Salt
CAS No.: 107220-28-0
Chemical Name: Cevimeline Hydrochloride Salt
Synonyms: SNK 508;Fks 508;Snd 5008;Saligren;CeviMelin;rac-Cevimeline HCl;AF-102B hydrochloride;SNI-2011 hydrochloride;Cevimelin Hydrochloride;CEVIMELINE, HYDROCHLORIDE SALT
CBNumber: CB72130375
Molecular Formula: C10H18ClNOS
Formula Weight: 235.77402
MOL File: 107220-28-0.mol

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Cevimeline Hydrochloride Salt Property

Melting point:: 195-197?C
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Water:50.0(Max Conc. mg/mL);212.07(Max Conc. mM)
form: A crystalline solid
color: White to off-white
Stability:: Hygroscopic
InChI: InChI=1S/C10H17NOS.ClH/c1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11;/h8-9H,2-7H2,1H3;1H
InChIKey: SURWTGAXEIEOGY-UHFFFAOYSA-N
SMILES: C1CC2C3(CSC(C)O3)CN1CC2.Cl

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Safety

Toxicity: mouse,LD50,intravenous,33mg/kg (33mg/kg),United States Patent Document. Vol. #4855290,

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17802
Product name: Cevimeline (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 17802
Product name: Cevimeline (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $98
Updated: 2024/03/01

Cayman Chemical

Product number: 17802
Product name: Cevimeline (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $161
Updated: 2024/03/01

TRC

Product number: C283500
Product name: rac,cis-CevimelineHydrochlorideSalt
Packaging: 10mg
Price: $145
Updated: 2021/12/16

TRC

Product number: C283500
Product name: rac,cis-CevimelineHydrochlorideSalt
Packaging: 25mg
Price: $335
Updated: 2021/12/16

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Cevimeline Hydrochloride Salt Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

A novel muscarinic M1 and M3 receptor agonist. Sialagogue.

Biological Activity

Selective M 1 receptor agonist. Induces atropine-sensitive contractions of isolated guinea pig ilea and trachea preparations (EC 50 values are 3.5 and 3 μ M respectively). Reverses AF64A-induced cognitive impairments in vivo .

in vivo

Cevimeline (0.008-0.016 mg/kg; intraperitoneal injection; male Wistar rats) treatment shows slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response. Cevimeline inhibits angiotensin II-induced water intake and neuronal activity in the subfornical organ at 0.016 mg/kg^[1].

Animal Model:	Male Wistar rats (8-week-old) injected with angiotensin-II^[1]
Dosage:	0.008 mg/kg, 0.016 mg/kg
Administration:	Intraperitoneal injection
Result:	Showed slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response.

IC 50

mAChR1; mAChR3

storage

-20°C

Cevimeline Hydrochloride Salt Preparation Products And Raw materials

Raw materials

Preparation Products

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Cevimeline Hydrochloride Salt Suppliers

Canada 1 China 58 India 6 United Kingdom 2 United States 14 Global 81

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Clearsynth Labs Limited

Tel: +91-22-26355700
Fax: +91-22-26355701
Email: info@clearsynth.com
Country: India
ProdList: 9679
Advantage: 58

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66028182 18626450290
Email: yftan@aikonchem.com
Country: China
ProdList: 16679
Advantage: 50

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

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View Lastest Price from Cevimeline Hydrochloride Salt manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.

Product: Cevimeline HCl; Cevimeline;AF102B 107220-28-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99.0%min. HPLC
Supply Ability: 1000kg
Release date: 2024-09-10

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