UNOPROSTONE Chemical Properties

Boiling point:

562.9±40.0 °C(Predicted)

Density 

1.069±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 25 mg/ml; DMSO: 17 mg/ml; Ethanol: 12 mg/ml; PBS (7.2): 90 μg/ml

pka

4.76±0.10(Predicted)

UNOPROSTONE Usage And Synthesis

Uses

Unoprostane is a protectant against retinal degeneration in S334ter rhodopsin mutant rats. Neuroprotective agent.

Definition

ChEBI: Unoprostone is an oxo monocarboxylic acid, a prostaglandins Falpha and a ketone. It has a role as an antiglaucoma drug and an antihypertensive agent.

General Description

Unoprostone (Rescula) is supplied as a 0.15% sterileophthalmic solution. Unoprostone is somewhat unusual inthat it is a docosanoid (22-carbon atom) PGF_2α analog marketedas the isopropyl ester. The natural 15-position alcoholis oxidized to the ketone as would be expected to occur invivo. Cautions and side effects are similar to those givenpreviously.

UNOPROSTONE(120373-36-6)Related Product Information

• UNOPROSTONE N-ETHYL AMIDE
• 13,14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA
• UNOPROSTONE
• isopropyl unoprostone,UNOPROSTONE ISOPROPYL ESTER
• cis-5-Eicosenoic acid