1-METHYLHYDANTOIN Chemical Properties

Melting point:

156-157 °C(lit.)

Boiling point:

213.59°C (rough estimate)

Density 

1.284

refractive index 

1.4487 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

8.94±0.10(Predicted)

form 

Solid

color 

White to Off-White

Water Solubility 

Soluble in methanol. (almost transparency). Insoluble in water.

CAS DataBase Reference

616-04-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Safety Statements 

24/25

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29332100

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1-METHYLHYDANTOIN Usage And Synthesis

Chemical Properties

WHITE FINE CRYSTALLINE POWDER

Uses

Reactant for organocatalytic tandem three component reactions of aldehyde, alkyl vinyl ketone, and amide

Reactant for synthesis of:

• Selective angiotensin II AT2 receptor agonists with reduced CYP 450 inhibition
• Allosteric glucokinase activators
• Hydantoin derivatives with antiproliferative activity
• Thiohydantoins
• P2X7 receptor antagonists

Definition

ChEBI: A imidazolidine-2,4-dione that is the N-methyl-derivative of hydantoin.

Metabolic pathway

The metabolic pathway of 1-methylhydantoin via 5-hydroxy-1-methylhydantoin, methylparabanic acid, and 5-N-methyloxaluric acid proves to be a major and general metabolic pathway in rabbits.

1-METHYLHYDANTOIN(616-04-6)Related Product Information

• Imidazolidinyl urea
• AKOS B028895
• 1-N-BUTYLHYDANTOIN
• 1-(4-CHLORO-PHENYL)-IMIDAZOLIDINE-2,4-DIONE
• 1,5,5-TRIMETHYLHYDANTOIN
• 6-HYDROXY-2-PHENYLTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOLE-1,3(2H)-DIONE
• Iprodione
• 1-METHYLHYDANTOIN
• 1-N-DODECYLHYDANTOIN
• 1,3-Bis(morpholinomethyl)-5-(p-methoxyphenyl)-5-methylhydantoin
• AKOS BBS-00002629
• AURORA KA-4130
• Dimethyloldimethyl hydantoin
• 1-N-HEXADECYLHYDANTOIN
• ETHYL 2,4,5-TRIOXOIMIDAZOLIDINE-1-ACETATE
• SALOR-INT L308773-1EA
• 1-[4,6-BIS(DIMETHYLAMINO)-1,3,5-TRIAZIN-2-YL]-3-(2-CHLOROETHYL)IMIDAZOLIDINE-2,4-DIONE
• 1-Benzyl hydantoin