1-METHYLHYDANTOIN Chemical Properties

Melting point:

156-157 °C(lit.)

Boiling point:

213.59°C (rough estimate)

Density 

1.284

refractive index 

1.4487 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

8.94±0.10(Predicted)

form 

Solid

color 

White to Off-White

Water Solubility 

Soluble in methanol. (almost transparency). Insoluble in water.

CAS DataBase Reference

616-04-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Safety Statements 

24/25

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29332100

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1-METHYLHYDANTOIN Usage And Synthesis

Chemical Properties

WHITE FINE CRYSTALLINE POWDER

Uses

Reactant for organocatalytic tandem three component reactions of aldehyde, alkyl vinyl ketone, and amide

Reactant for synthesis of:

• Selective angiotensin II AT2 receptor agonists with reduced CYP 450 inhibition
• Allosteric glucokinase activators
• Hydantoin derivatives with antiproliferative activity
• Thiohydantoins
• P2X7 receptor antagonists

Definition

ChEBI: A imidazolidine-2,4-dione that is the N-methyl-derivative of hydantoin.

Metabolic pathway

The metabolic pathway of 1-methylhydantoin via 5-hydroxy-1-methylhydantoin, methylparabanic acid, and 5-N-methyloxaluric acid proves to be a major and general metabolic pathway in rabbits.

1-METHYLHYDANTOIN(616-04-6)Related Product Information

• Imidazolidinyl urea
• 1,5,5-TRIMETHYLHYDANTOIN
• Iprodione
• 1-METHYLHYDANTOIN
• Dimethyloldimethyl hydantoin
• 1-Hydroxymethyl-5,5-dimethylhydantoin
• 1,3-dichloro-5,5’-methylhydantoi
• 1-METHYLHYDANTOIN-2-IMIDE HYDROCHLORIDE
• 3-(3,5-DICHLOROPHENYL)-1-METHYLHYDANTOIN(3-(3,5-DICHLOROPHENYL)-1-METHYL-2,4-IMIDAZOLIDINEDIONE)
• ((+/-)-5-Ethyl-(4-hydroxyphenyl)-3-methylhydantoin-D),(+/-)-5-Ethyl-(4-hydroxyphenyl)-3-methylhydantoin-d3
• 5-ETHYL-5-METHYLHYDANTOIN(MEH)
• 4-HYDROXY MEPHENYTOIN
• 1-BROMO-3-CHLORO-5-ETHYL-5-METHYLHYDANTOIN,1,3-Bromo-3-chloro-5-Methylhydantoin,1-BROMO-3-CHLORO-5-ETHYL-5-METHYLHYDANTOIN(BCMEH)
• 5-Ethyl-5-fenyl-3-methylhydantoin
• Creatinine
• 1-Methylhydantoin-d3-2-imide
• 5-ETHYL-5-METHYLHYDANTOIN
• 5-Methylhydantoin,98%,DL-5-METHYLHYDANTOIN,5-METHYLHYDANTOIN,(S)-5-Methylhydantoin