1,3-Dioxo-1H-benzo[de]isoquinoline-2(3H)-acetic acid sodium salt
1,3-Dioxo-1H-benzo[de]isoquinoline-2(3H)-acetic acid sodium salt Basic information
- Product Name:
- 1,3-Dioxo-1H-benzo[de]isoquinoline-2(3H)-acetic acid sodium salt
- Synonyms:
-
- 1,3-Dioxo-1H-benz[de]isoquinoline-2(3H)-acetic acid sodium salt
- 1,3-Dioxo-1H-benzo[de]isoquinoline-2(3H)-acetic acid sodium salt
- Alrestatin sodium
- AY-22284A
- sodium,2-(1,3-dioxobenzo[de]isoquinolin-2-yl)acetate
- Alrestatine sodium
- CAS:
- 51876-97-2
- MW:
- 0
- Mol File:
- 51876-97-2.mol
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1,3-Dioxo-1H-benzo[de]isoquinoline-2(3H)-acetic acid sodium salt Usage And Synthesis
Originator
Alrestatin,BIOMOL
Uses
Enzyme inhibitor (aldose reductase).
Manufacturing Process
1,3-Dioxo-1H-benz[de]isoquinoline-2(3H)-acetic acid:
1,8-Naphthalic acid anhydride (110 g, 0.556 mole), glycine (48 g, 0.64 mole)
and dimethylformamide (750 ml) are heated and stirred at reflux for 2 hr. The
homogeneous dark solution is cooled to about 100°C and 750 ml of hot water
is added slowly to the stirred solution. The reaction mixture is cooled and
allowed to stand in a refrigerator for 16 hr. The precipitate is collected and
recrystallized from ethanol, using decolorizing charcoal, to give the title
compound, MP: 271°-272°C.
In practice it is usually used as sodium salt.
Therapeutic Function
Aldose reductase inhibitor
1,3-Dioxo-1H-benzo[de]isoquinoline-2(3H)-acetic acid sodium saltSupplier
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