SC 57461A Chemical Properties

Melting point:

163-165°C

storage temp. 

Desiccate at +4°C

solubility 

DMSO: >5mg/mL

form 

powder

color 

white to off-white

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

26

WGK Germany 

3

SC 57461A Usage And Synthesis

Description

Leukotriene A₄ (LTA₄) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB₄ from LTA4 and cleaves the chemotactic peptide Pro-Gly-Pro. SC-57461A is a potent, orally active inhibitor of LTA₄ hydrolase that blocks ionophore-stimulated LTB₄ synthesis in whole blood (IC₅₀ = 49 nM). It blocks both the hydrolase and aminopeptidase activity in vitro. SC-57461A is without effect against other enzymes of the arachidonic acid cascade, including 5-lipoxygenase, LTC₄ synthase, COX-1, and COX-2. In a rat model of ionophore-induced peritoneal eicosanoid production, SC-57461A inhibits LTB₄ biosynthesis without affecting LTC₄ or 6-keto prostaglandin F_1α production . Oral or topical pretreatment with SC-57461A before challenge with arachidonic acid blocks ear edema in mice.

Chemical Properties

White Solid

Uses

SC 57461A is a potent and selective inhibitor of LTA4.

Uses

A potent and selective orally active leukotriene A4 hydrolase inhibitor.

Biological Activity

Potent and selective inhibitor of LTA 4 hydrolase. Does not inhibit other enzymes of the arachidonic acid cascade including COX-1, COX-2, LTC 4 synthase and 5-lipoxygenase. Potently inhibits LTB 4 production in whole blood (IC 50 = 49 nM). Orally active.

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