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SC 66

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SC 66 Basic information

Product Name:
SC 66
Synonyms:
  • SC 66
  • Cyclohexanone, 2,6-bis(4-pyridinylMethylene)-, (2E,6E)-
  • (2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone
  • CS-2480
  • SC66;SC 66
  • (2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone
  • Akt,SC 66,PKB,Protein kinase B,SC-66,SC66,Inhibitor,inhibit,Apoptosis
  • 2E,?6E-?BIS(4-?PYRIDINYLMETHYLENE)-?CYCLOHEXA
CAS:
871361-88-5
MF:
C18H16N2O
MW:
276.33
Mol File:
871361-88-5.mol
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SC 66 Chemical Properties

storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO: ≥5mg/mL (warmed)
form 
powder
color 
faint yellow to dark yellow
InChI
1S/C18H16N2O/c21-18-16(12-14-4-8-19-9-5-14)2-1-3-17(18)13-15-6-10-20-11-7-15/h4-13H,1-3H2/b16-12+,17-13+
InChIKey
CYVVJSKZRBZHAV-UNZYHPAISA-N
SMILES
O=C1\C(CCC\C1=C/c2ccncc2)=C\c3ccncc3
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Safety Information

WGK Germany 
3
Storage Class
13 - Non Combustible Solids
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SC 66 Usage And Synthesis

Description

Akt activation requires binding of its pleckstrin homology domain (PHD) to membrane-associated phosphatidylinositol-3,4,5-trisphosphate (PIP3) or phosphatidylinositol-3,4-bisphosphate (PIP2). Increased Akt activity, e.g., through a gain-of-function mutation in the PHD of Akt1, is pivotal to many types of cancer. Activated Akt may be regulated by various events, including ubiquitination-mediated deactivation. SC-66 is an allosteric inhibitor of Akt that facilitates both ubiquitination and deactivation of Akt. At 4 μg/ml, SC-66 inhibits Akt activity in HEK293T cells and in HEK293 cells stably expressing Akt with the gain-of-function pleckstrin homology domain mutation, promoting cell death. In nude mice inoculated with HEK293T cells, SC-66 (15 mg/kg) suppresses tumor growth.

Uses

SC 66 is an analog of curcumin that can inhibit the activity of ATP-binding cassette transporters in cancer multidrug resistance.

in vivo

To demonstrate the effectiveness in vivo of SC66 on HCC, a mouse xenograft tumor model of Hep3B cells is used. When tumors became palpable, at a size of about 150 mm3, mice are randomized into three groups of 6 animals each. The treated group receive SC66 at 15 and 25 mg/kg twice a week via i.p. injection, while the untreated group receive the vehicle alone. Treatment with 25 mg/Kg SC66 significantly reduces tumor volume to 37% on day 17 when compared with tumors of the untreated group[1].

storage

-20°C

References

[1] HAKRYUL JO. Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 16: 6486-6491. DOI: 10.1073/pnas.1019062108

SC 66Supplier

Shanghai Boyle Chemical Co., Ltd.
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sales@boylechem.com
MedChemexpress LLC
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021-58955995
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Bide Pharmatech Ltd.
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400-400-164-7117 18317119277
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product02@bidepharm.com
AdooQ Bioscience CHINA
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025-58849295 18951903616;
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info@adooq.cn
Shanghai JiYi Biotechnology Co. Ltd.
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13621943973
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sales@shjiyipharmatech.com
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SC 66(871361-88-5)Related Product Information