SC 66
SC 66 Basic information
- Product Name:
- SC 66
- Synonyms:
-
- SC 66
- Cyclohexanone, 2,6-bis(4-pyridinylMethylene)-, (2E,6E)-
- (2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone
- CS-2480
- SC66;SC 66
- (2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone
- Akt,SC 66,PKB,Protein kinase B,SC-66,SC66,Inhibitor,inhibit,Apoptosis
- 2E,?6E-?BIS(4-?PYRIDINYLMETHYLENE)-?CYCLOHEXA
- CAS:
- 871361-88-5
- MF:
- C18H16N2O
- MW:
- 276.33
- Mol File:
- 871361-88-5.mol
SC 66 Chemical Properties
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO: ≥5mg/mL (warmed)
- form
- powder
- color
- faint yellow to dark yellow
SC 66 Usage And Synthesis
Description
Akt activation requires binding of its pleckstrin homology domain (PHD) to membrane-
Uses
SC 66 is an analog of curcumin that can inhibit the activity of ATP-binding cassette transporters in cancer multidrug resistance.
in vivo
To demonstrate the effectiveness in vivo of SC66 on HCC, a mouse xenograft tumor model of Hep3B cells is used. When tumors became palpable, at a size of about 150 mm3, mice are randomized into three groups of 6 animals each. The treated group receive SC66 at 15 and 25 mg/kg twice a week via i.p. injection, while the untreated group receive the vehicle alone. Treatment with 25 mg/Kg SC66 significantly reduces tumor volume to 37% on day 17 when compared with tumors of the untreated group[1].
storage
-20°C
References
[1] HAKRYUL JO. Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 16: 6486-6491. DOI: 10.1073/pnas.1019062108
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