AWD-12-281 Chemical Properties

Density 

1.49±0.1 g/cm3(Predicted)

pka

7.34±0.70(Predicted)

AWD-12-281 Usage And Synthesis

Uses

AWD 12-281 is an orally active and highly selective phosphodiesterase 4 (PDE4) inhibitor (IC50 = 9.7 nM). AWD 12-281 is used in the study of allergic dermatitis, asthma, chronic obstructive pulmonary disease (COPD), and allergic rhinitis[1][2].

IC 50

PDE4: 9.7 nM (IC₅₀)

References

[1] Wolfgang B?umer, et al. AWD 12-281, a highly selective phosphodiesterase 4 inhibitor, is effective in the prevention and treatment of inflammatory reactions in a model of allergic dermatitis. J Pharm Pharmacol. 2003 Aug;55(8):1107-14. DOI:10.1211/0022357021585
[2] Regina Draheim, et al. Anti-inflammatory potential of the selective phosphodiesterase 4 inhibitor N-(3,5-dichloro-pyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyoxylic acid amide (AWD 12-281), in human cell preparations. J Pharmacol Exp Ther. 2004 Feb;308(2):555-63. DOI:10.1124/jpet.103.059097

AWD-12-281(257892-33-4)Related Product Information

• 2-(1H-INDOL-3-YL)-2-OXO-ETHYLAMINE HCL
• (3-(2-AMINOETHYL)-1-METHYLINDOLE) 2HCL
• AWD-12-281
• (3,5-DICHLORO-PYRIDIN-4-YL)METHYLAMINE
• 1-(4-FLUORO-BENZYL)-1H-INDOLE-3-CARBALDEHYDE