Methyl 2,6-dichloro-4-cyanobenzoate Chemical Properties

Boiling point:

319.6±42.0 °C(Predicted)

Density 

1.45

storage temp. 

Sealed in dry,Room Temperature

Appearance

White to off-white Solid

Methyl 2,6-dichloro-4-cyanobenzoate Usage And Synthesis

Synthesis

Step a: Synthesis of methyl 2,6-dichloro-4-cyanobenzoate Methyl 4-carbamoyl-2,6-dichlorobenzoate (100 mg, 0.4 mmol) was dissolved in pyridine (2 mL) and trifluoroacetic anhydride (0.11 mL, 0.8 mmol) was added slowly and dropwise at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 1 hour. Upon completion of the reaction, the mixture was poured into pre-cooled ice water, the precipitated solid was filtered, washed thoroughly with cold water and dried to afford methyl 2,6-dichloro-4-cyanobenzoate (55 mg, 88% yield) as an off-white solid.

References

[1] Patent: WO2012/160464, 2012, A1. Location in patent: Page/Page column 77-78
[2] Patent: US2014/155398, 2014, A1. Location in patent: Paragraph 0468
[3] Patent: US2010/317643, 2010, A1. Location in patent: Page/Page column 101
[4] Journal of Medicinal Chemistry, 2013, vol. 56, # 11, p. 4521 - 4536