(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol Chemical Properties

Melting point:

85-88℃

Boiling point:

288℃

Density 

1.170

Flash point:

128℃

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

Chloroform (Slightly), Methanol (Slightly)

pka

14.03±0.60(Predicted)

form 

Solid

color 

White to Pale Beige

optical activity

9.1°(C=0.30g/100ml CHCL3)

Stability:

Hygroscopic

InChI

InChI=1S/C8H15NO3/c1-8(2)11-6-4(9)3-5(10)7(6)12-8/h4-7,10H,3,9H2,1-2H3/t4-,5+,6+,7-/m1/s1

InChIKey

AXPYGRDXRLICKY-JRTVQGFMSA-N

SMILES

O1[C@@]2([H])[C@H](N)C[C@H](O)[C@@]2([H])OC1(C)C

Safety Information

HS Code 

2932990090

(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol Usage And Synthesis

Uses

(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol was used to preapare AZD6140 as an orally active reversible P2Y12 receptor antagonist for prevention of thrombosis.

Synthesis

0.86 g of p-toluenesulfonic acid was added to a solution of 15.0 g of the precursor compound in acetone ( 250 ml ) followed by 22 ml of 2,2 -dimethoxypropane, and the resulting reaction mixture was stirred at room temperature for 30 minutes. At the end of the reaction the mixture was separated by extraction between ethyl acetate ( 700 ml ) and brine ( 300 ml ), the organic layer was separated and concentrated, water was added to the residue, which was heated and refluxed for 24 h. At the end of the reaction the reaction solution was concentrated under reduced pressure and azeotropized with toluene to remove water to give (3AR,4S,6R,6AS)-6-aminotetrahydro-2,2-dimethyl-4H- cyclopenteno-1,3-dioxolan-4-ol.

(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol(155899-66-4)Related Product Information

• (3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)aMino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyriMidin-3-yl)-2,2-
• 2-(((3aR,4S,6R,6aS)-6-(7-aMino-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyriMidin-3-yl)-2,2-diMethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol
• Ticagrelor Sulfone
• 2-((3aS,4R,6S,6aR)-4-aminotetrahydro-3aH-spiro[cyclopenta[d][1,3]dioxole-2,1'-cyclopentane]-6-yloxy)ethanol oxalic acid salt
• Ticagrelor iMpurity
• (1S,2S,3R,5S)-3-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)aMino)-5-(propylsulfinyl)-3H-[1,2,3]triazolo[4,5-d]pyriMidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol
• TICAGRELOR
• 2-((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)ethanol L-tataric acid
• 4,6-dichloro-2-propylthiopyrimidine-5-amine
• 4,6-DICHLORO-5-NITRO-2-PROPYLTHIOPYRIMIDINE
• (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate
• 1-Acetyladamantane Intermediate
• (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine. HCl
• Ethanol, 2-[[(3aR,4S,6R,6aS)-6-[[5-aMino-6-chloro-2-(propylthio)-4-pyriMidinyl]aMino]tetrahydro-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-
• ethyCyclopropanamine, 2-(3,4-difluorophenyl)-, (1R,2S)- (REACH)
• (1R,2R)-2-(3,4-difluorophenyl)cyclopropane carboxaMide
• (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine
• CarbaMicacid,N-[(3aS,4R,6S,6aR)-tetrahydro-6-hydroxy-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-yl]-,phenylMethyl ester